连续的过敏原激发导致支气管反应性降低。

Consecutive allergen challenges resulted in decreased bronchial responsiveness.

作者信息

He Jianxin, Jiang Zaifang

机构信息

Respiratory Department, Beijing Children's Hospital, Capital University of Medical Sciences, Beijing 100045, China.

出版信息

Chin Med J (Engl). 2002 Nov;115(11):1727-9.

PMID:12609095

Abstract

OBJECTIVE

To investigate bronchial responsiveness to acetylcholine in allergic airway inflammation of SD rats.

METHODS

SD rats were immunized and challenged by chicken ovalbumin (OVA). Airway responsiveness, acetylcholine (Ach) provocation concentration needed to increase baseline airway resistance by 200% (PC(200)) were measured.

RESULTS

The value of baseline airway resistance in asthma group was significantly higher than that in control group (2.282 +/- 0.128 vs 3.193 +/- 0.239; P < 0.01). After multiple ovalbumin exposures, airway responsiveness to intravenous injection of acetylcholine decreased significantly (-LogPC(200): 4.006 +/- 0.554 vs 2.059 +/- 0.262; P < 0.01). Bronchial alveolar lavage fluid (BALF) and lung tissue specimen analysis indicated that airway allergic inflammation was present.

CONCLUSIONS

The study demonstrates a dissociation between the bronchoconstrictor response and bronchial hyper-responsiveness and indicates that multiple ovalbumin exposures induces persistent bronchoconstriction with airway hypo-responsiveness despite airway allergic inflammation.

摘要

目的

研究SD大鼠变应性气道炎症中支气管对乙酰胆碱的反应性。

方法

用鸡卵清蛋白（OVA）对SD大鼠进行免疫和激发。测量气道反应性、使基线气道阻力增加200%所需的乙酰胆碱（Ach）激发浓度（PC(200)）。

结果

哮喘组基线气道阻力值显著高于对照组（2.282±0.128对3.193±0.239；P<0.01）。多次接触卵清蛋白后，静脉注射乙酰胆碱的气道反应性显著降低（-LogPC(200)：4.006±0.554对2.059±0.262；P<0.01）。支气管肺泡灌洗液（BALF）和肺组织标本分析表明存在气道变应性炎症。