Millan Ernesto, Abou-Khalil Bassel, Delbeke Dominique, Konrad Peter
Epilepsy Behav. 2001 Feb;2(1):54-60. doi: 10.1006/ebeh.2001.0147.
Generalized absence seizures are rarely reported to originate from one frontal lobe. We report an 8-year-old girl with atypical absence seizures demonstrated to be of right frontal origin by ictal positron emission tomography (PET). She had a congenital left hemiparesis and intractable seizures since age 3, and was referred for epilepsy surgery. During electroencephalography-video monitoring numerous episodes of atypical absence seizures were recorded in association with generalized 3- to 3.3-Hz spike-and-wave discharges by EEG. PET was performed with simultaneous EEG recording. Six typical seizures occurred during the fluorodeoxyglucose (FDG) uptake period. The PET scan demonstrated marked increased FDG uptake in right frontal region. Partial seizures of frontal lobe origin can manifest themselves as atypical absence seizures, with generalization based on secondary bilateral synchrony. In patients with frequent seizures the frontal seizure origin may be demonstrated noninvasively with functional imaging using PET or single-photon emission computed tomography.
全身性失神发作很少被报道起源于一侧额叶。我们报告一名8岁女孩，其非典型失神发作经发作期正电子发射断层扫描（PET）证实起源于右侧额叶。她自3岁起患有先天性左侧偏瘫和难治性癫痫，被转诊接受癫痫手术。在脑电图-视频监测期间，记录到大量非典型失神发作事件，脑电图显示伴有全身性3至3.3赫兹棘慢波放电。PET检查时同时进行脑电图记录。在氟脱氧葡萄糖（FDG）摄取期发生了6次典型发作。PET扫描显示右侧额叶区域FDG摄取明显增加。额叶起源的部分性发作可表现为非典型失神发作，并基于继发性双侧同步化而泛化。对于频繁发作的患者，使用PET或单光子发射计算机断层扫描等功能成像可无创地显示额叶癫痫起源。
