Hasty Paul, Campisi Judith, Hoeijmakers Jan, van Steeg Harry, Vijg Jan
Department of Molecular Medicine, University of Texas Health Science Center, San Antonio, TX 78245, USA.
Science. 2003 Feb 28;299(5611):1355-9. doi: 10.1126/science.1079161.
Recent progress in the science of aging is driven largely by the use of model systems, ranging from yeast and nematodes to mice. These models have revealed conservation in genetic pathways that balance energy production and its damaging by-products with pathways that preserve somatic maintenance. Maintaining genome integrity has emerged as a major factor in longevity and cell viability. Here we discuss the use of mouse models with defects in genome maintenance for understanding the molecular basis of aging in humans.
衰老科学的最新进展在很大程度上得益于模型系统的应用，这些模型系统涵盖了从酵母、线虫到小鼠等多种生物。这些模型揭示了遗传途径中的保守性，即平衡能量产生及其有害副产物的途径与维持体细胞维持的途径之间的保守性。维持基因组完整性已成为长寿和细胞活力的一个主要因素。在此，我们讨论利用基因组维持存在缺陷的小鼠模型来理解人类衰老的分子基础。
