β-N-乙酰己糖胺酶催化转糖基化合成6'-磺基二糖
Synthesis of 6'-sulfodisaccharides by beta-N-acetylhexosaminidase-catalyzed transglycosylation.
作者信息
Uzawa Hirotaka, Zeng Xiaoxiong, Minoura Norihiko
机构信息
Laboratory of Advanced Bioelectronics, National Institute of Advanced Industrial Science and Technology (AIST), Central 5, 1-1-1 Higashi, Tsukuba 305-8565, Japan.
出版信息
Chem Commun (Camb). 2003 Jan 7(1):100-1. doi: 10.1039/b209893h.
DOI:10.1039/b209893h
PMID:12610985
Abstract
Presulfated N-acetylglucosaminyl donor (pNP beta-D-6-SO3-GlcNAc) was applied for the synthesis of sulfosugars using the beta-N-acetylhexosaminidase-catalyzed transglycosylation, to afford the critically stereocontrolled sulfodisaccharides carrying the 6-sulfo GlcNAc residue at the non-reducing sides in one step.
摘要
预硫酸化的N-乙酰葡糖胺供体（对硝基苯β-D-6-磺酸基-GlcNAc）用于通过β-N-乙酰己糖胺酶催化的转糖基化反应合成磺基糖，一步得到在非还原端带有6-磺酸基GlcNAc残基的具有关键立体控制的磺基二糖。
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