Tsukada Fumitake, Nagura Yoko, Abe Shinya, Sato Naoko, Ohkubo Yasuhito
Department of Radiopharmacy, Tohoku Pharmaceutical University, Aoba-ku, Sendai, Japan.
Biol Pharm Bull. 2003 Mar;26(3):368-70. doi: 10.1248/bpb.26.368.
We investigated the effects of restraint and footshock stress and norepinephrine treatment on gastric emptying. The gastric emptying was significantly inhibited by restraint stress. beta(3)-adrenergic antagonist canceled the inhibition of gastric emptying caused by restraint stress, while beta(1)-, beta(2)-, alpha(1)-, and alpha(2)-adrenergic antagonists did not affect the inhibition. Norepinephrine treatment also inhibited gastric emptying. The inhibition by norepinephrine treatment was canceled by beta(1)-, beta(2)-, and beta(3)-adrenergic antagonists, but not by alpha(1)- and alpha(2)-adrenergic antagonists. On the other hand, footshock stress did not affect gastric emptying. These results suggest that beta(3)-adrenoceptors play an important role in the inhibition of gastric emptying caused by restraint stress, while nonspecific beta-adrenoceptors are involved in that caused by norepinephrine treatment.
我们研究了束缚和足底电击应激以及去甲肾上腺素处理对胃排空的影响。束缚应激显著抑制胃排空。β(3)-肾上腺素能拮抗剂可消除束缚应激引起的胃排空抑制，而β(1)-、β(2)-、α(1)-和α(2)-肾上腺素能拮抗剂对该抑制无影响。去甲肾上腺素处理也抑制胃排空。β(1)-、β(2)-和β(3)-肾上腺素能拮抗剂可消除去甲肾上腺素处理引起的抑制，但α(1)-和α(2)-肾上腺素能拮抗剂则不能。另一方面，足底电击应激不影响胃排空。这些结果表明，β(3)-肾上腺素能受体在束缚应激引起的胃排空抑制中起重要作用，而非特异性β-肾上腺素能受体参与了去甲肾上腺素处理引起的胃排空抑制。
