Zhang H, Tian M, Oriuchi N, Higuchi T, Watanabe H, Aoki J, Tanada S, Endo K
Department of Nuclear Medicine, Gunma University School of Medicine, Maebashi, Gunma, Japan.
Nucl Med Commun. 2003 Mar;24(3):273-9. doi: 10.1097/00006231-200303000-00007.
We assessed and compared the usefulness of C-choline positron emission tomography (PET) with that of 2-[ F]fluoro-2-deoxy-D-glucose (FDG) PET for the differentiation between benign and malignant bone and soft tissue tumours. A total of 43 patients with 45 lesions were included. C-choline PET and FDG PET were performed from 5 and 40 min, respectively, after injection of 275-370 MBq tracer. PET data were evaluated by using the standardized uptake value (SUV) and were analysed according to the pathological data. C-choline uptake in malignancies was 4.9+/-2.1 (n=14), which was significantly higher than that in benign lesions (2.5+/-1.7, n=31) (P <0.0001). The sensitivity, specificity and accuracy of C-choline PET were 100%, 64.5% and 75.6%, respectively, when 2.59 of the SUV was used as the cut-off value. The FDG uptake in malignancies was 5.1+/-4.2 (n=14) and was also significantly larger than that in benign lesions 2.9+/-2.9 (n=31) (P<0.003). The sensitivity, specificity and accuracy of FDG PET were 85.7%, 41.9% and 55.6%, respectively (cut-off=1.83). The C-choline uptake in the lesions correlated with FDG uptake ( r=0.61, P<0.003). In receiver operating characteristic (ROC) analysis, the area under the ROC curve for C-choline PET (area=0.847) was higher than that for FDG PET (area=0.717). This study showed that C-choline PET was superior to FDG PET in differentiation between malignant and benign lesion in bone and soft tissue tumours. C-choline PET might be useful as a screening method for malignant bone and soft tissue tumours.
我们评估并比较了碳 - 胆碱正电子发射断层扫描（PET）与2 - [F]氟 - 2 - 脱氧 - D - 葡萄糖（FDG）PET在鉴别良恶性骨与软组织肿瘤方面的效用。共纳入43例患者的45个病灶。分别在注射275 - 370 MBq示踪剂后5分钟和40分钟进行碳 - 胆碱PET和FDG PET检查。PET数据采用标准化摄取值（SUV）进行评估，并根据病理数据进行分析。恶性肿瘤中碳 - 胆碱摄取量为4.9±2.1（n = 14），显著高于良性病灶（2.5±1.7，n = 31）（P < 0.0001）。以SUV 2.59作为临界值时，碳 - 胆碱PET的敏感性、特异性和准确性分别为100%、64.5%和75.6%。恶性肿瘤中FDG摄取量为5.1±4.2（n = 总述14），也显著高于良性病灶（2.9±2.9，n = 31）（P < 0.003）。FDG PET的敏感性、特异性和准确性分别为85.7%、41.9%和55.6%（临界值 = 1.83）。病灶中的碳 - 胆碱摄取与FDG摄取相关（r = 0.61，P < 0.003）。在受试者工作特征（ROC）分析中，碳 - 胆碱PET的ROC曲线下面积（面积 = 0.847）高于FDG PET（面积 = 0.717）。本研究表明，在鉴别骨与软组织肿瘤的良恶性病变方面，碳 - 胆碱PET优于FDG PET。碳 - 胆碱PET可能作为恶性骨与软组织肿瘤的一种筛查方法。
