[11C]胆碱正电子发射断层显像（PET）对鼻腔和鼻窦肿瘤的诊断：与2-[18F]氟-2-脱氧-D-葡萄糖（FDG）PET的对比研究
Diagnosis of tumor in the nasal cavity and paranasal sinuses with [11C]choline PET: comparative study with 2-[18F]fluoro-2-deoxy-D-glucose (FDG) PET.
作者信息
Ninomiya Hiroshi, Oriuchi Noboru, Kahn Nasim, Higuchi Tetsuya, Endo Keigo, Takahashi Katsumasa, Chikamatsu Kazuaki, Kamada Hideo, Furuya Nobuhiko
机构信息
Department of Otolaryngology-Head and Neck Surgery, Gunma University Graduate School of Medicine, Maebashi, Japan.
出版信息
Ann Nucl Med. 2004 Feb;18(1):29-34. doi: 10.1007/BF02985611.
[11C]choline (11C-choline) positron emission tomography (PET) was performed to evaluate its clinical utility in the diagnosis of tumors in the nasal cavity and paranasal sinuses. We studied 22 patients with suspicion of malignant tumors in the nasal cavity and paranasal sinuses. Tumor uptake of 11C-choline was measured with standardized uptake value (SUV) and correlated with the pathological diagnosis. 2-[18F]fluoro-2-deoxy-D-glucose (FDG) PET was performed in all patients for comparison. Both 11C-choline and FDG PET depicted squamous cell carcinoma showing an increased activity significantly higher than that of normal tissue, and these SUVs were significantly higher than those of benign lesions. FDG uptake in malignant tumors as a whole was variable. Although 11C-choline uptake in squamous cell carcinoma was lower than FDG uptake, 11C-choline uptake in malignant tumors was relatively uniform and statistical significance was found. PET with 11C-choline may be useful to diagnosis tumors in the nasal cavity and paranasal sinuses.
进行了[11C]胆碱（11C-胆碱）正电子发射断层扫描（PET）以评估其在鼻腔和鼻窦肿瘤诊断中的临床效用。我们研究了22例怀疑患有鼻腔和鼻窦恶性肿瘤的患者。用标准化摄取值（SUV）测量11C-胆碱的肿瘤摄取，并将其与病理诊断相关联。对所有患者均进行了2-[18F]氟-2-脱氧-D-葡萄糖（FDG）PET检查以作比较。11C-胆碱PET和FDG PET均显示鳞状细胞癌的活性增加，明显高于正常组织，且这些SUV显著高于良性病变。恶性肿瘤整体的FDG摄取情况不一。虽然鳞状细胞癌中11C-胆碱的摄取低于FDG摄取，但恶性肿瘤中11C-胆碱的摄取相对均匀，且具有统计学意义。11C-胆碱PET可能有助于鼻腔和鼻窦肿瘤的诊断。
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