Ishimura Eiji, Okuno Senji, Marukawa Taro, Katoh Yoshikazu, Hiranaka Toshiyuki, Yamakawa Tomoyuki, Morii Hirotoshi, Kim Masao, Matsumoto Naoki, Shoji Tetsuo, Inaba Masaaki, Nakatani Tatsuya, Nishizawa Yoshiki
Department of Nephrology, Osaka City University Graduate School of Medicine and Shirasagi Hospital Kidney Center, Osaka, Japan.
Am J Kidney Dis. 2003 Mar;41(3 Suppl 1):S137-41. doi: 10.1053/ajkd.2003.50103.
Changes in body fat mass in a large number of hemodialysis patients is unknown.
Body fat mass and lean body mass were measured by dual x-ray absorptiometry (DXA) in 561 patients with hemodialysis duration less than 180 months (62.3 +/- 11.5 years old; mean +/- SD).
Fat mass tended to increase during the first 3 years of hemodialysis, and it tended to decrease thereafter. Between hemodialysis duration and the fat mass index, there was a significant positive correlation within the first 36-month period of hemodialysis (r = 0.124; P < 0.05; n = 245), and a significant negative correlation during the period of 36 to 180 months. (r = -0.192; P < 0.001; n = 316). There was no tendency of change in the lean body mass index.
Considering the results together with the authors previous prospective study results, which show significant fat mass increase in the first year of hemodialysis, the present cross-sectional study may suggest that fat mass gradually increases in the first 3 years and decreases thereafter. Fat mass is suggested to be a nutritional parameter in hemodialysis patients.
大量血液透析患者体脂质量的变化尚不清楚。
采用双能X线吸收法（DXA）测量了561例血液透析时间少于180个月的患者（62.3±11.5岁；均值±标准差）的体脂质量和去脂体重。
血液透析的前3年，脂肪质量呈增加趋势，此后呈下降趋势。在血液透析的前36个月内，血液透析时间与脂肪质量指数之间存在显著正相关（r = 0.124；P < 0.05；n = 245），而在36至180个月期间存在显著负相关（r = -0.192；P < 0.001；n = 316）。去脂体重指数无变化趋势。
结合作者之前的前瞻性研究结果（显示血液透析第一年脂肪质量显著增加）来看，本横断面研究可能表明，脂肪质量在最初3年逐渐增加，此后减少。脂肪质量被认为是血液透析患者的一个营养参数。
