Chng Wee J, Tan Lip K, Liu Te C
Department of Haematology/Oncology, National University Hospital, Singapore 119074.
Am J Kidney Dis. 2003 Mar;41(3):692-5. doi: 10.1053/ajkd.2003.50132.
Human recombinant erythropoietin is the main treatment for anemia in renal patients. Recently, there have been case reports of pure red blood cell aplasia (PRCA) developing in renal patients administered erythropoietin, probably because of neutralizing antibodies detected in all these patients. All reports were from the West, and most patients were treated with erythropoietin-alpha. Cyclosporine is an immunosuppressive agent used to treat a spectrum of autoimmune conditions. We report a series of Chinese renal patients who developed PRCA after treatment with erythropoietin-alpha, suggesting that this is a problem worldwide. They were treated successfully with cyclosporine and became transfusion independent.
重组人促红细胞生成素是治疗肾病患者贫血的主要药物。最近，有病例报告称，接受促红细胞生成素治疗的肾病患者出现了纯红细胞再生障碍性贫血（PRCA），这可能是因为在所有这些患者中都检测到了中和抗体。所有报告均来自西方，大多数患者接受了α-促红细胞生成素治疗。环孢素是一种免疫抑制剂，用于治疗一系列自身免疫性疾病。我们报告了一系列中国肾病患者，他们在接受α-促红细胞生成素治疗后出现了PRCA，这表明这是一个全球性问题。他们接受环孢素治疗后成功治愈，不再依赖输血。
