Shalev E, Stojan B, Fahrländer H
Dtsch Med Wochenschr. 1976 Apr 30;101(18):685-7. doi: 10.1055/s-0028-1104159.
Collagen-peptidase activity in serum was increased in 54 of 71 cases of Crohn's disease. This increase was highly significant (P less than 0.001) compared with the results in a control group (24 cases). Immunosuppressive drugs (corticosteroids, azathioprine) decreased collagen-peptidase activity in the patients with Crohn's disease. On average it was higher than that of patients with sarcoidosis. Further tests are required to establish whether collagen-peptidase activity is of diagnostic value in Crohn's disease.
71例克罗恩病患者中，54例血清胶原肽酶活性升高。与对照组（24例）结果相比，这种升高具有高度显著性（P<0.001）。免疫抑制药物（皮质类固醇、硫唑嘌呤）可降低克罗恩病患者的胶原肽酶活性。平均而言，其高于结节病患者。需要进一步检测以确定胶原肽酶活性在克罗恩病中是否具有诊断价值。
