Falchuk K R, Perrotto J L, Isselbacher K J
Gastroenterology. 1975 Oct;69(4):893-6.
Serum lysozyme concentrations were determined in patients with clinically active and inactive Crohn's disease as well as in healthy volunteers. The mean serum lysozyme concentrations (+/- SE) for each group were as follows: controls, 8.8 +/- 0.4; active Crohn's disease, 20.8 +/- 0.8; and inactive Crohn's disease, 10.4 +/- 0.7 mug per ml. The mean lysozyme level was significantly greater in active Crohn's disease as compared to normal subjects (P less than 0.001) and patients with inactive disease (P less than 0.001). Moreover, in patients with clinically severe Crohn's disease there seems to be a trend toward greater lysozyme levels, as opposed to those with mild to moderately active disease. In patients followed serially during the course of their disease, serum lysozyme levels increased with exacerbations of the illness and decreased with clinical improvement. These findings suggest that the serum lysozyme concentrations may serve as a useful index of the activity of Crohn's disease and aid in monitoring the clinical course of such patients.
对临床活动期和非活动期克罗恩病患者以及健康志愿者测定了血清溶菌酶浓度。每组的平均血清溶菌酶浓度（±标准误）如下：对照组，8.8±0.4；活动期克罗恩病患者，20.8±0.8；非活动期克罗恩病患者，10.4±0.7微克/毫升。与正常受试者（P<0.001）和非活动期疾病患者（P<0.001）相比，活动期克罗恩病患者的平均溶菌酶水平显著更高。此外，与轻度至中度活动期疾病患者相比，临床重度克罗恩病患者似乎有溶菌酶水平更高的趋势。在疾病过程中接受连续观察的患者中，血清溶菌酶水平随病情加重而升高，随临床改善而降低。这些发现表明，血清溶菌酶浓度可能是克罗恩病活动度的一个有用指标，并有助于监测此类患者的临床病程。
