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了解多倍体中新型基因表达的机制。

Understanding mechanisms of novel gene expression in polyploids.

作者信息

Osborn Thomas C, Pires J Chris, Birchler James A, Auger Donald L, Chen Z Jeffery, Lee Hyeon-Se, Comai Luca, Madlung Andreas, Doerge R W, Colot Vincent, Martienssen Robert A

机构信息

Dept of Agronomy, University of Wisconsin, Madison, WI 53706, USA.

出版信息

Trends Genet. 2003 Mar;19(3):141-7. doi: 10.1016/s0168-9525(03)00015-5.

Abstract

Polyploidy has long been recognized as a prominent force shaping the evolution of eukaryotes, especially flowering plants. New phenotypes often arise with polyploid formation and can contribute to the success of polyploids in nature or their selection for use in agriculture. Although the causes of novel variation in polyploids are not well understood, they could involve changes in gene expression through increased variation in dosage-regulated gene expression, altered regulatory interactions, and rapid genetic and epigenetic changes. New research approaches are being used to study these mechanisms and the results should provide a more complete understanding of polyploidy.

摘要

长期以来,多倍体一直被认为是塑造真核生物进化的一股重要力量,尤其是开花植物。新的表型常常随着多倍体的形成而出现,并且有助于多倍体在自然环境中的成功繁衍或在农业中的选择利用。尽管多倍体中新变异的成因尚未完全明确,但可能涉及通过剂量调控基因表达的增加变异、改变的调控相互作用以及快速的遗传和表观遗传变化来改变基因表达。新的研究方法正被用于研究这些机制,其结果将使我们对多倍体有更全面的理解。

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