用于电位法测定某些药物制剂中盐酸甲氧氯普胺的聚氯乙烯基质膜传感器。

PVC matrix membrane sensor for potentiometric determination of metoclopramide hydrochloride in some pharmaceutical formulations.

作者信息

Mostafa G A E

机构信息

Microanalytical Laboratory, Applied Organic Chemistry Department, National Research Center, Dokki, Cairo, Egypt.

出版信息

J Pharm Biomed Anal. 2003 Mar 10;31(3):515-21. doi: 10.1016/s0731-7085(02)00676-3.

DOI:10.1016/s0731-7085(02)00676-3

PMID:12615239

Abstract

The construction and characteristic performance of metoclopramide (MCP)-polyvinyl chloride (PVC) membrane sensor are described. The sensor is based on the use of MCP-tetraiodomercurate ion pair as electroactive material in PVC matrix in presence of dioctylphthalate (DOP) as solvent mediator. MCP membrane sensor shows a stable, near Nernstian response over the concentration range 1 x 10(-2)-6 x 10(-5) M of MCP at 25 degrees C in the pH range 3-7 with cationic slope of 53.0+/-0.5. The detection limit of 4 x 10(-5) M and the response time of 30-60 s have been attained. Selectivity coefficient data for some common ions show negligible intereferences. Direct potentiometric determination of 15-3540 microg/ml MCP show an average recovery of 98.5% and a mean relative standard deviation (R.S.D.) of 1.6% at 100.0 microg/ml. The determination of MCP in Primperan tablets, injection, and syrup gave results that compare favorably with those obtained by the British pharmacopoeia method. Precipitation titrations involving MCP as titrant are monitored with the MCP sensor for some potentiometric precipitation reaction, e.g. sodium tetraphenylborate (STPB) and phosphomolybdic acid (PMA).

摘要

描述了甲氧氯普胺（MCP）-聚氯乙烯（PVC）膜传感器的构建及其特性。该传感器基于在邻苯二甲酸二辛酯（DOP）作为溶剂介质的情况下，将MCP-四碘汞酸离子对用作PVC基质中的电活性材料。MCP膜传感器在25℃、pH值为3至7的条件下，对浓度范围为1×10⁻²至6×10⁻⁵ M的MCP表现出稳定的近能斯特响应，阳离子斜率为53.0±0.5。检测限达到4×10⁻⁵ M，响应时间为30至60秒。一些常见离子的选择性系数数据显示干扰可忽略不计。对15至3540微克/毫升的MCP进行直接电位测定，在100.0微克/毫升时平均回收率为98.5%，平均相对标准偏差（R.S.D.）为1.6%。在胃复安片、注射液和糖浆中测定MCP的结果与英国药典方法所得结果相比良好。对于一些电位沉淀反应，如用四苯硼酸钠（STPB）和磷钼酸（PMA），以MCP作为滴定剂的沉淀滴定用MCP传感器进行监测。