Holmes Clive, Lovestone Simon
University of Southampton, Clinical Neurosciences Research Division, Memory Assessment and Research Centre, Moorgreen Hospital, Botley Road, Southampton SO30 3JB, UK.
Age Ageing. 2003 Mar;32(2):200-4. doi: 10.1093/ageing/32.2.200.
National Institute of Clinical Excellence guidelines advocate the use of the Mini-Mental Test Examination and a functional assessment as a means of measuring treatment response. However, there is little knowledge of the change expected in those with Alzheimer's disease in clinical practice.
to describe the long-term variability of the Mini-Mental Test Examination and Blessed Dementia Rating Scale.
374 Alzheimer's disease patients referred to psychiatric services in southeast London were followed annually over a 3-year period.
the mean Mini-Mental Test Examination score for the total group at baseline was 9.9 points. Individual variability in the rate of cognitive and functional decline is large and around 40% of patients after 1 year, and up to one-quarter of patients after 3 years who survived, show no change or an improvement in scores compared with baseline measures.
in the evaluation of individual treatment response the rate of change, as measured by the Mini-Mental Test Examination and Blessed Dementia Rating Scale, is of limited value.
英国国家临床优化研究所指南提倡使用简易精神状态检查表和功能评估作为衡量治疗反应的手段。然而，在临床实践中，对于阿尔茨海默病患者预期的变化了解甚少。
描述简易精神状态检查表和布氏痴呆评定量表的长期变异性。
对伦敦东南部转介至精神科服务的374例阿尔茨海默病患者进行了为期3年的年度随访。
总体组在基线时的简易精神状态检查表平均得分为9.9分。认知和功能衰退率的个体变异性很大，1年后约40%的患者以及3年后存活患者中多达四分之一的患者与基线测量相比，分数没有变化或有所改善。
在评估个体治疗反应时，通过简易精神状态检查表和布氏痴呆评定量表衡量的变化率价值有限。
