Shukla Yogeshwer, Arora Annu, Taneja Pankaj
Environmental Carcinogenesis Division, Industrial Toxicology Research Centre, Lucknow, India.
Teratog Carcinog Mutagen. 2003;Suppl 1:323-35. doi: 10.1002/tcm.10059.
The human diet contains a variety of compounds that exhibit chemopreventive effects towards an array of xenobiotics. In the present study, the antigenotoxic potential of selected dietary constituents including Diallyl sulfide (DAS), Indole-3-carbinol (I3C), Curcumin (CUR), and Black tea polyphenols (BTP) has been evaluated in the Salmonella typhimurium reverse mutation and mammalian in vivo cytogenetic assays. In addition, the anticlastogenic effect of the above dietary constituents was identified towards Benzo(a)pyrene (BaP) and cyclophosphamide- (CP) induced cytogenetic damage in mouse bone marrow cells. The induction of BaP and CP induced chromosomal aberrations, micronuclei formation, and sister chromatid exchanges (SCEs) were found to be inhibited in a dose-dependent manner by DAS, I3C, CUR, and BTP. Thus the study reveals the antimutagenic potential of these dietary compounds towards BaP- and CP-induced genotoxicity in microbial and mammalian test systems.
人类饮食中含有多种对一系列外源性物质具有化学预防作用的化合物。在本研究中，已在鼠伤寒沙门氏菌回复突变试验和哺乳动物体内细胞遗传学试验中评估了所选膳食成分（包括二烯丙基硫醚（DAS）、吲哚 - 3 - 甲醇（I3C）、姜黄素（CUR）和红茶多酚（BTP））的抗遗传毒性潜力。此外，还确定了上述膳食成分对苯并(a)芘（BaP）和环磷酰胺（CP）诱导的小鼠骨髓细胞细胞遗传学损伤的抗断裂效应。发现DAS、I3C、CUR和BTP以剂量依赖性方式抑制BaP和CP诱导的染色体畸变、微核形成和姐妹染色单体交换（SCE）。因此，该研究揭示了这些膳食化合物在微生物和哺乳动物测试系统中对BaP和CP诱导的遗传毒性的抗诱变潜力。
