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红茶多酚、茶黄素和茶红素在多种测试系统中对苯并[a]芘诱导的致突变性和遗传毒性的抑制作用

Inhibition of benzo[a]pyrene induced mutagenicity and genotoxicity by black tea polyphenols theaflavins and thearubigins in multiple test systems.

作者信息

Halder Babli, Pramanick Swapan, Mukhopadhyay Sibabrata, Giri Ashok Kumar

机构信息

Division of Human Genetics and Genomics, Indian Institute of Chemical Biology, 4, Raja S. C. Mullick Road, Jadavpur, Kolkata-700032, West Bengal, India.

出版信息

Food Chem Toxicol. 2005 Apr;43(4):591-7. doi: 10.1016/j.fct.2005.01.002.

DOI:10.1016/j.fct.2005.01.002

PMID:15721207

Abstract

This study investigated the antimutagenic and anticlastogenic effects of black tea polyphenols, theaflavins (TF) and thearubigins (TR) in Salmonella assay in vitro and in vivo in bone marrow cells of mice as measured by chromosomal aberrations (CA) and sister chromatid exchange (SCE) against a known carcinogen, benzo[a]pyrene (B[a]P). A significant decrease in mutagenicity in Salmonella assay and both CA and SCE were observed in all the different concentrations of TF and TR plus B[a]P treated series when compared with B[a]P treated group alone. These results indicate that both TF and TR have significant antimutagenic and anticlastogenic effects.

摘要

本研究通过体外沙门氏菌试验以及在小鼠骨髓细胞体内试验，以染色体畸变（CA）和姐妹染色单体交换（SCE）为指标，测定了红茶多酚、茶黄素（TF）和茶红素（TR）对已知致癌物苯并[a]芘（B[a]P）的抗诱变和抗断裂作用。与单独用B[a]P处理的组相比，在所有不同浓度的TF和TR加B[a]P处理组中，沙门氏菌试验中的诱变性以及CA和SCE均显著降低。这些结果表明，TF和TR均具有显著的抗诱变和抗断裂作用。