Clark Gary D
Departments of Pediatrics, Neurology, and Neuroscience, Cain Foundation Laboratories, 6621 Fannin Street, MC 3-6365, Houston, TX 77030-2399, USA.
Neurol Clin. 2002 Nov;20(4):917-39. doi: 10.1016/s0733-8619(02)00024-5.
The progress made in the understanding of the genetics of human brain malformations has lead to insight into the formation of brain and into mechanisms of disease affecting brain. It bears upon neurologists and geneticists to recognize the patterns of diseases of brain formation, to properly diagnose such disorders, to assess the recurrence risk of these malformations, and to guide families with appropriate expectations for outcomes. This article may serve as a guide to neurologists in their approach to these disorders. Because this area is one of rapid progress, the clinician is advised to seek more current information that may be available through on-line databases and other sources.
在人类脑畸形遗传学理解方面取得的进展，已使人们深入了解大脑的形成以及影响大脑的疾病机制。神经学家和遗传学家有责任识别脑形成疾病的模式，正确诊断此类疾病，评估这些畸形的复发风险，并引导家庭对结果抱有适当期望。本文可作为神经学家处理这些疾病的指南。由于该领域进展迅速，建议临床医生通过在线数据库和其他来源获取更多最新信息。
