三维伪连续动脉自旋标记灌注成像在自闭症儿童脑部的应用
Application of Three-Dimensional Pseudocontinuous Arterial Spin Labeling Perfusion Imaging in the Brains of Children With Autism.
作者信息
Tang Shilong, Liu Xianfan, Ran Qiying, Nie Lisha, Wu Lan, Pan Zhengxia, He Ling
机构信息
Department of Radiology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing, China.
GE Healthcare, MR Research China, Beijing, China.
出版信息
Front Neurol. 2022 Feb 23;13:851430. doi: 10.3389/fneur.2022.851430. eCollection 2022.
OBJECTIVE
To explore the application of three-dimensional pseudocontinuous arterial spin labeling (3D-PCASL) perfusion imaging in the brains of children with autism and to understand the characteristics of cerebral blood perfusion in children with autism.
METHODS
A total of 320 children with autism (160 men and 160 women) aged between 2 and 18 years and 320 age- and sex-matched healthy children participated in the study. All children were scanned by 3.0 T magnetic resonance axial T1 fluid-attenuated inversion recovery (FLAIR), T2 FLAIR, 3D-T1, and 3D-PCASL sequences. After postprocessing, cerebral blood flow (CBF) values in each brain region of children with autism and healthy children at the same age were compared and analyzed. Furthermore, CBF characteristics in each brain region of autistic children at various ages were determined.
RESULTS
The CBF values of the frontal lobe, hippocampus, temporal lobe, and caudate nucleus of children with autism are lower than those of healthy children ( < 0.05). Additionally, as the ages of children with autism increase, the number of brain regions with decreased CBF values gradually increases. A receiver operating characteristic (ROC) analysis results show that the CBF values of the frontal lobe, hippocampus, temporal lobe, and caudate nucleus can distinguish children with autism [area under the ROC curve (AUC) > 0.05, < 0.05].
CONCLUSION
The 3D-PCASL shows lower brain CBF values in children with autism.
CLINICAL TRIAL REGISTRATION
www.ClinicalTrials.gov, identifier: ChiCTR2000034356.
目的
探讨三维伪连续动脉自旋标记（3D - PCASL）灌注成像在自闭症儿童脑内的应用，了解自闭症儿童脑血流灌注特点。
方法
选取320例年龄在2至18岁之间的自闭症儿童（男160例，女160例）以及320例年龄、性别相匹配的健康儿童参与研究。所有儿童均接受3.0T磁共振轴位T1液体衰减反转恢复（FLAIR）、T2 FLAIR、3D - T1及3D - PCASL序列扫描。经后处理后，比较并分析自闭症儿童与同年龄健康儿童各脑区的脑血流量（CBF）值。此外，确定不同年龄段自闭症儿童各脑区的CBF特征。
结果
自闭症儿童额叶、海马、颞叶及尾状核的CBF值低于健康儿童（<0.05）。此外，随着自闭症儿童年龄增长，CBF值降低的脑区数量逐渐增加。受试者工作特征（ROC）分析结果显示，额叶、海马、颞叶及尾状核的CBF值可区分自闭症儿童[ROC曲线下面积（AUC）>0.05，<0.05]。
结论
3D - PCASL显示自闭症儿童脑CBF值较低。
临床试验注册
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