Nakashima Yoko, Ikegami Sachie
Department of Human Life and Culture, Seitoku University, 550 Iwase Matsudo-city, Chiba 271-8555, Japan.
J Agric Food Chem. 2003 Mar 12;51(6):1628-33. doi: 10.1021/jf020869w.
To investigate the influence of a high-fat diet on HCB distribution and accumulation, pregnant rats in study 1 were fed a high-fat or control diet containing HCB, and, in study 2, pregnant rats were given a single HCB dose by intragastric gavage and HCB-free high-fat or control diet. In study 1, the high-fat diet group had higher HCB concentrations in fat tissues and liver than did the controls. In study 2, although the total amounts of HCB in the fat tissue and liver were greater in the high-fat diet group than in the controls, no significant differences in HCB concentration were observed between the two groups. The high-fat diet group also showed more fecal excretion of HCB. Therefore, HCB accumulation in rats fed a high-fat diet was enhanced more by continuous exposure to HCB than by administration of a single dose.
为研究高脂饮食对六氯苯（HCB）分布和蓄积的影响，研究1中给怀孕大鼠喂食含HCB的高脂或对照饮食，在研究2中，通过灌胃给怀孕大鼠单次给予HCB，并给予不含HCB的高脂或对照饮食。在研究1中，高脂饮食组脂肪组织和肝脏中的HCB浓度高于对照组。在研究2中，尽管高脂饮食组脂肪组织和肝脏中HCB的总量高于对照组，但两组之间HCB浓度未观察到显著差异。高脂饮食组的HCB粪便排泄量也更多。因此，持续接触HCB比单次给药更能增强高脂饮食喂养大鼠体内的HCB蓄积。
