Reumaux Dominique, Sendid Boualem, Poulain Daniel, Duthilleul Patrick, Dewit O, Colombel Jean-Frédéric
Département d'Hématologie-Immunologie-Cytogénétique, CH Valenciennes, Lille, France.
Best Pract Res Clin Gastroenterol. 2003 Feb;17(1):19-35. doi: 10.1053/bega.2002.0347.
This chapter is an overview of the literature on serological markers of inflammatory bowel diseases (IBD), focusing on anti-neutrophil cytoplasm autoantibodies (ANCA) and anti- Saccharomyces cerevisiae mannan antibodies (ASCA). The methodology for ANCA and ASCA testing is first introduced. The value of these markers as diagnostic tools is then discussed. Other chapters are devoted to the potential role of ANCA and ASCA in disease monitoring, disease stratification and as subclinical markers in families. Finally reviewed are other antibodies recently tested in clinical trials such as pancreatic antibodies and antibodies directed against bacterial antigens. The role of these antibodies in the pathophysiology of IBD still needs to be assessed. We also need to identify the ASCA immunogen(s) eliciting the antibody response.
本章是关于炎症性肠病（IBD）血清学标志物文献的概述，重点关注抗中性粒细胞胞浆自身抗体（ANCA）和抗酿酒酵母甘露聚糖抗体（ASCA）。首先介绍了ANCA和ASCA检测方法。然后讨论了这些标志物作为诊断工具的价值。其他章节专门论述了ANCA和ASCA在疾病监测、疾病分层以及作为家族中亚临床标志物的潜在作用。最后回顾了近期在临床试验中检测的其他抗体，如胰腺抗体和针对细菌抗原的抗体。这些抗体在IBD病理生理学中的作用仍有待评估。我们还需要确定引发抗体反应的ASCA免疫原。
