Kyriakidi Kallirroi S, Tsianos Vasileios E, Karvounis Evaggelos, Christodoulou Dimitrios K, Katsanos Konstantinos H, Tsianos Epameinondas V
Research Laboratory of Immunology (Kallirroi S. Kyriakidi, Vasileios E. Tsianos, Evaggelos Karvounis), Ioannina, Greece.
Division of Gastroenterology (Dimitrios K. Christodoulou, Konstantinos H. Katsanos), Ioannina, Greece.
Ann Gastroenterol. 2016 Jul-Sep;29(3):258-67. doi: 10.20524/aog.2016.0028. Epub 2016 Mar 24.
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract comprising Crohn's disease and ulcerative colitis. Although the pathogenesis of the disease is not clearly defined yet, environmental, genetic and other factors contribute to the onset of the disease. Apart from the clinical and histopathological findings, several serological biomarkers are also employed to detect IBD. One of the most thoroughly studied biomarker is anti-neutrophil cytoplasmic autoantibody (ANCA). We herein provide an overview of the current knowledge on the use of ANCA and certain ANCA proteins, such as bactericidal increasing protein, lactoferrin, cathepsin G and elastase, as serological markers for IBD and other diseases.
炎症性肠病（IBD）是一种胃肠道的慢性炎症性疾病，包括克罗恩病和溃疡性结肠炎。尽管该疾病的发病机制尚未明确，但环境、遗传和其他因素都与疾病的发生有关。除了临床和组织病理学检查结果外，几种血清生物标志物也被用于检测IBD。研究最深入的生物标志物之一是抗中性粒细胞胞浆自身抗体（ANCA）。我们在此概述了关于使用ANCA和某些ANCA蛋白（如杀菌增强蛋白、乳铁蛋白、组织蛋白酶G和弹性蛋白酶）作为IBD及其他疾病血清标志物的当前知识。
