Row Barry W, Goldbart Aviv, Gozal Evelyne, Gozal David
Kosair Children's Hospital Research Institute, Department of Pediatrics, University of Louisville, Baxter Biomedical Research Building, Suite 321, 570 South Preston Street, Louisville, KY 40202, USA.
Neurosci Lett. 2003 Mar 13;339(1):67-71. doi: 10.1016/s0304-3940(02)01459-3.
Intermittent hypoxia (IH), such as occurs in sleep apnea, is associated with increased apoptosis and neurobehavioral impairments in rats. To determine whether pre-training (P) modifies the effect of IH on spatial learning, adult male rats were trained in a spatial version of the water maze, exposed to IH or room air (RA) for 14 days, and then trained in a novel spatial task. P-RA had lower initial pathlengths than naive RA (N-RA), which were similar in P-IH and N-IH, indicating an adverse effect of IH on retention of behavioral strategies to solve the maze. However, P-IH acquired the later spatial task faster than N-IH. Pre-training was associated with increased phosphorylation of the cAMP-response element binding protein (CREB) in the hippocampus. Further, IH-induced decreases in CREB phosphorylation were attenuated by pre-training. We conclude that prior exposure to the water maze behavioral requirements attenuates the behavioral deficits occurring after IH exposure.
间歇性低氧（IH），如发生在睡眠呼吸暂停时的情况，与大鼠体内凋亡增加及神经行为障碍有关。为了确定预训练（P）是否会改变IH对空间学习的影响，成年雄性大鼠在水迷宫的空间版本中接受训练，暴露于IH或室内空气（RA）中14天，然后在一项新的空间任务中接受训练。预训练组暴露于室内空气（P-RA）的初始路径长度比未经训练暴露于室内空气的大鼠（N-RA）短，而预训练组暴露于间歇性低氧（P-IH）和未经训练暴露于间歇性低氧的大鼠（N-IH）的初始路径长度相似，这表明IH对解决迷宫行为策略的保持有不利影响。然而，预训练组暴露于间歇性低氧（P-IH）比未经训练暴露于间歇性低氧的大鼠（N-IH）更快地学会了后来的空间任务。预训练与海马体中cAMP反应元件结合蛋白（CREB）磷酸化增加有关。此外，预训练减弱了IH诱导的CREB磷酸化减少。我们得出结论，先前接触水迷宫行为要求可减轻IH暴露后出现的行为缺陷。
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