Soluble VEGF receptor Flt1: the elusive preeclampsia factor discovered?
作者信息
Luttun Aernout, Carmeliet Peter
机构信息
The Center for Transgene Technology and Gene Therapy, Flanders Interuniversitary Institute for Biotechnology, Katholieke Universiteit Leuven, Leuven, Belgium.
出版信息
J Clin Invest. 2003 Mar;111(5):600-2. doi: 10.1172/JCI18015.
Abstract
摘要
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本文引用的文献
1
Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases.
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2
Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia.
J Clin Invest. 2003 Mar;111(5):649-58. doi: 10.1172/JCI17189.
3
Preeclampsia. Part 1: clinical and pathophysiologic considerations.
Obstet Gynecol Surv. 2002 Sep;57(9):598-618. doi: 10.1097/00006254-200209000-00023.
4
Loss of the VEGF(164) and VEGF(188) isoforms impairs postnatal glomerular angiogenesis and renal arteriogenesis in mice.
J Am Soc Nephrol. 2002 Jun;13(6):1548-60. doi: 10.1097/01.asn.0000013925.19218.7b.
5
Regulation of trophoblast invasion: from normal implantation to pre-eclampsia.
Mol Cell Endocrinol. 2002 Feb 22;187(1-2):233-8. doi: 10.1016/s0303-7207(01)00687-6.
6
Vascular endothelial growth factor ligands and receptors that regulate human cytotrophoblast survival are dysregulated in severe preeclampsia and hemolysis, elevated liver enzymes, and low platelets syndrome.
Am J Pathol. 2002 Apr;160(4):1405-23. doi: 10.1016/S0002-9440(10)62567-9.
7
Pathogenesis and genetics of pre-eclampsia.
Lancet. 2001 Jan 6;357(9249):53-6. doi: 10.1016/s0140-6736(00)03577-7.
8
Animal models of preeclampsia.
Semin Perinatol. 1999 Feb;23(1):2-13. doi: 10.1016/s0146-0005(99)80055-x.
9
Ultrastructural differentiation of stromal and vascular components in early macaque placental villi.
Am J Anat. 1987 Jan;178(1):30-44. doi: 10.1002/aja.1001780105.
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