Simko Elemir, Wilcock Brian P, Yager Julie A
Department of Veterinary Pathology, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon S7N 5B4.
Can Vet J. 2003 Jan;44(1):38-42.
Apocrine sweat gland adenocarcinomas (AACs) are relatively uncommon skin tumors in dogs. Little prognostic or behavioral information has been published for these tumors. In this retrospective study, 44 AACs from diagnostic archives were reexamined and clinical postexcisional follow-ups for 25 of the 44 cases were obtained by a survey. There were 28 out of 44 (65.9%) AACs that invaded the capsule, stroma, or both, 5 of 44 (11.4%) invaded blood vessels and stroma, and 1 out of 25 (4%) had distant metastases. The presence or absence of stromal and vascular invasion was predicted by clinical examination with more than 80% accuracy. Postexcisional median survival of dogs with AACs was 30 mo at the time of survey. Determination of a correlation between histological features and malignant behavior of AACs was compromised by the low number of cases with clinical AAC-related problems; however, it appears that intravascular invasion is an important indicator of potential systemic metastases.
顶泌汗腺腺癌（AACs）是犬类相对罕见的皮肤肿瘤。关于这些肿瘤的预后或行为信息鲜有发表。在这项回顾性研究中，对诊断档案中的44例顶泌汗腺腺癌进行了重新检查，并通过调查获得了其中25例病例的临床切除后随访情况。44例（65.9%）顶泌汗腺腺癌侵犯了包膜、基质或两者，44例中的5例（11.4%）侵犯了血管和基质，25例中的1例（4%）发生了远处转移。通过临床检查预测基质和血管侵犯的存在与否，准确率超过80%。在调查时，患有顶泌汗腺腺癌的犬的切除后中位生存期为30个月。由于临床顶泌汗腺腺癌相关问题的病例数量较少，确定顶泌汗腺腺癌组织学特征与恶性行为之间的相关性受到了影响；然而，血管内侵犯似乎是潜在全身转移的一个重要指标。
