Caruso Salvatore, Roccasalva Lucia, Di Fazio Enza, Sapienza Gloria, Agnello Carmela, Ficarra Simona, Di Mari Lucia, Serra Agostino
Research Group for Sexology, Department of Microbiological Science and Gynecological Science, School of Medicine University of Catania, Italy.
Fertil Steril. 2003 Mar;79(3):543-9. doi: 10.1016/s0015-0282(02)04844-6.
To investigate the effects of hormone therapy (HT) on nasal respiratory epithelium in postmenopausal women.
Prospective open clinical trial.
Outpatient menopausal clinic.
PATIENT(S): One hundred three healthy postmenopausal women, of whom 55 treated with HT, and 48 untreated women (controls).
INTERVENTION(S): Different regimens of HT by patch, gel, or oral administration.
MAIN OUTCOME MEASURE(S): Cytologic changes of nasal, middle and inferior turbinate cells compared with vaginal cytologic findings by using the maturation index.
RESULT(S): Hematoxylin-eosin staining for the maturation index confirmed similar trophic cytologic aspects between the nasal respiratory epithelium and vaginal smears in HT-treated women and controls. Women treated with sequential HT or estrogen therapy (ET) showed better trophic characteristics in the nasal cytological samples compared with women treated with continuous combined HT.
CONCLUSION(S): Along with vaginal cells the nasal respiratory epithelium is an estrogen target. The activity of HT in the nasal respiratory epithelium may depend on the type of hormone regimen used.
探讨激素疗法（HT）对绝经后女性鼻呼吸上皮的影响。
前瞻性开放临床试验。
门诊更年期诊所。
103名健康绝经后女性，其中55名接受HT治疗，48名未治疗女性（对照组）。
通过贴片、凝胶或口服给予不同方案的HT。
使用成熟指数，将鼻、中鼻甲和下鼻甲细胞的细胞学变化与阴道细胞学检查结果进行比较。
苏木精-伊红染色的成熟指数证实，HT治疗的女性和对照组的鼻呼吸上皮与阴道涂片之间在滋养细胞学方面相似。与接受连续联合HT治疗的女性相比，接受序贯HT或雌激素疗法（ET）治疗的女性在鼻细胞学样本中表现出更好的滋养特征。
鼻呼吸上皮与阴道细胞一样，是雌激素的靶器官。HT在鼻呼吸上皮中的活性可能取决于所使用的激素方案类型。
