Caruso Salvatore, Maiolino Luigi, Agnello Carmela, Garozzo Aldo, Di Mari Lucia, Serra Agostino
Research Group for Sexology, Department of Microbiological Science and Gynecological Science, University of Catania School of Medicine, Italy.
Fertil Steril. 2003 Mar;79(3):556-61. doi: 10.1016/s0015-0282(02)04763-5.
To study the effects of gonadal steroids on the nongenital audiological target in surgically postmenopausal women treated with patch or gel transdermal estrogen therapy (ET).
Prospective randomized study.
Research Group for Sexology, University of Catania, Italy.
PATIENT(S): One hundred twenty-two surgically postmenopausal women.
INTERVENTION(S): Transdermal E(2) by patch or gel, and evaluation of auditory brainstem response by auditory-evoked potentials for waves I, III, and V latencies, and for interpeak I-III, I-V, and III-V intervals.
MAIN OUTCOME MEASURE(S): Changes in auditory wave latencies and in interpeak intervals during treatment with ET with respect to baseline levels.
RESULT(S): One hundred two women completed the study. Forty-eight subjects used E(2) patches and 54 E(2) gel. No significant difference was observed in plasma E(2) improvement and in auditory brainstem response values with the two estrogen (E) formulations. The wave latencies and the interpeak intervals showed lower values during the E treatment than at baseline.
CONCLUSION(S): Auditory brainstem response seems to depend on the type of E given. Our data suggest that fluctuating E levels act on waves, even if the exact mechanism of the gonadal steroids is not clear. However, we believe that E could influence neuronal plasticity, the metabolic levels of neurotransmitters, and thus, the neuronal conduction time into the audiological system.
研究性腺类固醇对采用经皮贴剂或凝胶经皮雌激素治疗（ET）的手术绝经后女性非生殖系统听力学指标的影响。
前瞻性随机研究。
意大利卡塔尼亚大学性学研究组。
122例手术绝经后女性。
采用贴剂或凝胶经皮给予雌二醇（E₂），并通过听觉诱发电位评估听觉脑干反应的I、III和V波潜伏期以及I-III、I-V和III-V峰间间期。
ET治疗期间听觉波潜伏期和峰间间期相对于基线水平的变化。
102例女性完成研究。48例受试者使用E₂贴剂，54例使用E₂凝胶。两种雌激素（E）制剂在血浆E₂改善情况和听觉脑干反应值方面未观察到显著差异。E治疗期间波潜伏期和峰间间期的值低于基线水平。
听觉脑干反应似乎取决于所给予E的类型。我们的数据表明，即使性腺类固醇的确切机制尚不清楚，E水平的波动也会对波产生影响。然而，我们认为E可能影响神经元可塑性、神经递质的代谢水平，进而影响听觉系统中的神经元传导时间。
