[Assessment of the alkaline (ALP) and acid phosphatase (ACP) in the blood serum of rats during experimental postmenopausal osteoporosis].

The aim of this study was to evaluate the activity of alkaline (ALP) and acid (ACP) phosphatase in the blood serum of rats after ovariectomy and with estrogen replacement therapy. The relationship between mandible and spine bone mineral density (BMD) and parameters of bone remodeling was also estimated. The concentration of serum total alkaline and acid phosphatase was higher in the rats with estrogen deficiency, and statistically lower in rats administering 17 beta-estradiol. ALP and ACP levels were correlated significantly negative with mandible and spine BMD. Carried out examinations confirmed increasing bone resorption during experimental postmenopausal osteoporosis.