Whelan Mike, Whelan Joseph, Russell Nick, Dalgleish Angus
Onyvax, St George's Hospital Medical School, Cranmer Terrace, London, UK SW17 0RE.
Drug Discov Today. 2003 Mar 15;8(6):253-8. doi: 10.1016/s1359-6446(03)02633-3.
There is clear evidence that certain forms of immunotherapy can be successful against certain cancers. However, it would appear that cancerous cells of various origin are exceptionally adept at subverting the immune response. Consequently, it is probable that the most efficacious therapy will be one in which multiple responses of the immune system are activated. There is currently an embarrassment of riches with regard to multiple vaccine strategies in the clinic, although no single method seems to hold the solution. Here, we draw together several of the humoral- and cellular-activating strategies currently under clinical investigation.
有明确证据表明，某些形式的免疫疗法对某些癌症可能有效。然而，各种起源的癌细胞似乎特别善于破坏免疫反应。因此，最有效的疗法可能是激活免疫系统多种反应的疗法。目前临床上有多种疫苗策略可供选择，令人应接不暇，尽管似乎没有一种单一方法能解决问题。在此，我们汇总了目前正在临床研究中的几种体液和细胞激活策略。
