由非手性二炔脂质进行的手性微管自组装。
Chiral tubule self-assembly from an achiral diynoic lipid.
作者信息
Pakhomov Serhii, Hammer Robert P, Mishra Bijaya K, Thomas Britt N
机构信息
Department of Chemistry, Louisiana State University, Baton Rouge, LA 70808, USA.
出版信息
Proc Natl Acad Sci U S A. 2003 Mar 18;100(6):3040-2. doi: 10.1073/pnas.0030051100. Epub 2003 Mar 7.
Abstract
Tubules possessing microm-scale chiral substructure self-assemble from an achiral isomer of the tubule-forming diynoic phosphatidylcholine, 1,2-bis(10,12-tricosadiynoyl)sn-glycero-3-phosphocholine [DC(8,9)PC], showing that molecular chirality is not essential for tubule formation. CD spectroscopy shows that these structures' helical sense of handedness instead originates in a spontaneous cooperative chiral symmetry-breaking process. We conclude that the chiral symmetry-breaking must originate in the unusual feature common to the chiral and achiral tubule-forming molecules, the diynes centered in their hydrocarbon tails.
摘要
具有微米级手性亚结构的微管由形成微管的二炔磷脂酰胆碱的非手性异构体1,2-双(10,12-二十三碳二炔酰基)-sn-甘油-3-磷酸胆碱[DC(8,9)PC]自组装而成，这表明分子手性对于微管形成并非必不可少。圆二色光谱表明，这些结构的螺旋手性方向相反，起源于自发的协同手性对称破缺过程。我们得出结论，手性对称破缺必定起源于手性和非手性微管形成分子共有的异常特征，即位于其烃链尾部中心的二炔。
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