活化蛋白C抵抗（FV（莱顿））与血栓形成：导致高凝状态的凝血因子V突变

Activated protein C resistance (FV(Leiden)) and thrombosis: factor V mutations causing hypercoagulable states.

作者信息

Nicolaes Gerry A F, Dahlbäck Björn

机构信息

Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Post Office Box 616, 6200 MD, Maastricht, The Netherlands.

出版信息

Hematol Oncol Clin North Am. 2003 Feb;17(1):37-61, vi. doi: 10.1016/s0889-8588(02)00097-7.

DOI:10.1016/s0889-8588(02)00097-7

PMID:12627662

Abstract

The integrity of the vascular system is of prime importance for survival. Therefore, several emergency and repair systems safeguard the circulatory system. Multiple processes jointly limit vascular damage and blood loss. In this article, the authors focus on the protein C anticoagulant pathway and the role of activated protein C resistance in thrombotic disease, and they discuss the involvement in thrombosis of mutations other than the Arg506Gln mutation in the gene encoding for factor V.

摘要

血管系统的完整性对于生存至关重要。因此，有几种应急和修复系统保护着循环系统。多种过程共同限制血管损伤和失血。在本文中，作者重点关注蛋白C抗凝途径以及活化蛋白C抵抗在血栓形成性疾病中的作用，并且他们讨论了除因子V编码基因中的Arg506Gln突变以外的其他突变在血栓形成中的作用。