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某些酰肼及其类似物的合成与体外抗利什曼原虫活性

Synthesis and in vitro leishmanicidal activity of some hydrazides and their analogues.

作者信息

Khan Khalid Mohammad, Rasheed Maimona, Hayat Safdar, Kaukab Farhana, Choudhary M Iqbal, Perveen Shahnaz

机构信息

International Center for Chemical Sciences, HEJ Research Institute of Chemistry, University of Karachi, -75270, Karachi, Pakistan.

出版信息

Bioorg Med Chem. 2003 Apr 3;11(7):1381-7. doi: 10.1016/s0968-0896(02)00611-9.

DOI:10.1016/s0968-0896(02)00611-9
PMID:12628664
Abstract

Twenty-one hydrazides were synthesized by treating different esters with hydrazine hydrate. Substituted hydrazides were obtained by treating hydrazides with alkyl/aryl/acyl halides. Some of these compounds exhibit potential in vitro leishmanicidal activity. The structures of all the synthesized compounds were confirmed by spectroscopic analysis.

摘要

通过用水合肼处理不同的酯合成了21种酰肼。通过用烷基/芳基/酰基卤化物处理酰肼得到取代酰肼。这些化合物中的一些表现出潜在的体外杀利什曼原虫活性。所有合成化合物的结构均通过光谱分析得以确证。

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