Otellin V A, Korzhevskiĭ D E
Department of Morphology, RAMS Scientific Research Institute of Experimental Medicine, St. Petersburg.
Morfologiia. 2002;122(6):14-8.
Using the methods of light and electron microscopy and immunocytochemistry, the barrier structures on the outer surface of the forming human brain were studied in the early prenatal period of development. The data obtained suggest that the superficial barrier in the forming brain is heteromorphous and consists of differently specialized morpho-functional complexes. The areas of contact of developing brain surface with blood capillaries of pericerebral vascular network were found to be the zone of the blood-brainbarrier formation, while the areas of the surface bordering the meningeal extracellular matrix were the zone of future liquor-brain barrier.
采用光学显微镜、电子显微镜和免疫细胞化学方法，对人类大脑形成早期产前阶段大脑外表面的屏障结构进行了研究。所获得的数据表明，正在形成的大脑中的表面屏障是异形的，由不同专门化的形态功能复合体组成。发现发育中的脑表面与脑周血管网络的毛细血管接触的区域是血脑屏障形成的区域，而与脑膜细胞外基质相邻的表面区域是未来脑脊液-脑屏障的区域。
