Amara F, Simpson L, Ghanem Y, Abdel-Aati T, Korani M A, Youssef E, El-Sheikh S
Unit of Metabolism and Diabetes, Alexandria University, Alexandria, Egypt.
Clin Hemorheol Microcirc. 2003;28(1):21-8.
The aim of this work was to study the red cell morphology in different stages of schistosomiasis. Patients were divided into three groups according to the stage of the disease. For each patient, complete clinical examination, liver function tests, renal function tests, complete blood picture, scanning electron microscopy for erythrocytes (SEM) and abdominal ultrasonography were done. Abnormal morphologic changes of a total discoid flat cells of 70.14%, margin changes of 12.34% and 3.55% of cup forms were found. To our knowledge, these marked changes were not reported in any other disease. No statistical differences were found between red cell shape changes and stage of liver disease. There was a positive correlation between portal vein diameter and percentage of flat discoid forms and a negative correlation between surface changes and clinical stage of liver disease. These changes are known to be accompanied by reduction of red cell deformability and impaired capillary flow.
这项工作的目的是研究血吸虫病不同阶段的红细胞形态。根据疾病阶段将患者分为三组。对每位患者进行了全面的临床检查、肝功能测试、肾功能测试、全血细胞计数、红细胞扫描电子显微镜检查（SEM）和腹部超声检查。发现盘状扁平细胞总数有70.14%出现异常形态变化，12.34%有边缘变化，3.55%出现杯状形态变化。据我们所知，这些显著变化在其他任何疾病中均未报道。红细胞形状变化与肝病阶段之间未发现统计学差异。门静脉直径与扁平盘状形态百分比呈正相关，表面变化与肝病临床阶段呈负相关。已知这些变化会伴随着红细胞变形性降低和毛细血管血流受损。
