1q增益是乳腺叶状肿瘤中常见的异常情况。
Gain in 1q is a common abnormality in phyllodes tumours of the breast.
作者信息
Jee Kowan J, Gong Gyungyub, Ahn Sei Hyun, Park Jeong Mi, Knuutila Sakari
机构信息
Departments of Pathology and Medical Genetics, Haartman Institute and Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland.
出版信息
Anal Cell Pathol. 2003;25(2):89-93. doi: 10.1155/2003/803192.
We studied DNA copy number changes by CGH and allelic imbalance (AI) on 3p by LOH analysis on 22 phyllodes tumours (PT) of the breast in order to gain insight into the genetic basis of tumour progression in PT. Copy number changes were observed in 14 cases (63%). Gain in 1q with 1q21-23 as the minimal overlapping area was seen in 12 cases (55%). The gain was observed both in benign and malignant tumours. Our study did not reveal any DNA copy number changes or allelic loss on 3p. The results suggest that DNA copy number changes are not associated with the histological grade or clinical behaviour of PT and the chromosomal changes on 3p appear to be rare. Colour figure can be viewed on http://www.esacp.org/acp/2003/25-2/jee.htm
我们通过比较基因组杂交（CGH）研究了DNA拷贝数变化，并通过对22例乳腺叶状肿瘤（PT）进行3p杂合性缺失（LOH）分析来检测等位基因失衡（AI），以便深入了解PT肿瘤进展的遗传基础。14例（63%）观察到拷贝数变化。12例（55%）出现1q增益，最小重叠区域为1q21 - 23。在良性和恶性肿瘤中均观察到增益。我们的研究未发现3p上有任何DNA拷贝数变化或等位基因缺失。结果表明，DNA拷贝数变化与PT的组织学分级或临床行为无关，3p上的染色体变化似乎很少见。彩色图可在http://www.esacp.org/acp/2003/25 - 2/jee.htm查看
Zotero 插件