Guo Hai-Qiang, Guan Peng, Shi Hai-Long, Zhang Xuan, Zhou Bao-Sen, Yuan Yuan
Department of Epidemiology, College of Public Health, China Medical University, Shenyang 110001, Liaoning Province, China.
World J Gastroenterol. 2003 Mar;9(3):432-6. doi: 10.3748/wjg.v9.i3.432.
To evaluate the preliminary effects of comprehensive prevention of gastric cancer in Zhuanghe County epidemiologically.
Stratified sampling and cluster sampling were applied to define the intervention group and the control group. The prospective cohort study was used for evaluating the effect of preventing gastric cancer. The relative risk (RR) and attributable risk percent (AR %) of intervention on gastric cancer death were calculated. Potential years of life lost (PLYY) of the disease was analyzed, and the RR and AR % of PYLL were calculated. Survival analysis was applied among the screened patients.
In the first 4 years after intervening, the relative risk (RR) of intervention on death was 0.5059 (95 % CI: 0.3462-0.7392, P<0.05) with significance statistically. AR % of the intervention on death was 49.41 %. The RR of intervention on cumulative PYLL was 0.6778 (95 % CI: 0.5604-0.8198, P<0.05) with statistic significance. AR % of the intervention on cumulative PYLL was 30.32 %. The four-year survival rate of the screened patients was 0.6751 (95 % CI: 0.5298-0.9047).
The initiative intervention results showed that the intervention approach used in the trial was effective, it reduced mortality and increased survival rate, and alleviated the adverse effect of gastric cancer on the health and life of screened population.
从流行病学角度评估庄河县胃癌综合预防的初步效果。
采用分层抽样和整群抽样确定干预组和对照组。采用前瞻性队列研究评估胃癌预防效果。计算干预对胃癌死亡的相对危险度（RR）和归因危险度百分比（AR%）。分析该疾病潜在寿命损失年（PYLL），并计算PYLL的RR和AR%。对筛查出的患者进行生存分析。
干预后的前4年，干预对死亡的相对危险度（RR）为0.5059（95%可信区间：0.3462 - 0.7392，P<0.05），具有统计学意义。干预对死亡的AR%为49.41%。干预对累积PYLL的RR为0.6778（95%可信区间：0.5604 - 0.8198，P<0.05），具有统计学意义。干预对累积PYLL的AR%为30.32%。筛查出患者的四年生存率为0.6751（95%可信区间：0.5298 - 0.9047）。
主动干预结果表明，试验中采用的干预方法有效，降低了死亡率，提高了生存率，减轻了胃癌对筛查人群健康和生活的不利影响。
