Tumor Etiology and Screening Department of Cancer Institute and General Surgery, The First Affiliated Hospital of China Medical University, Key Laboratory of Cancer Control in Liaoning Province, Shenyang 110001, Liaoning Province, China.
World J Gastroenterol. 2012 Mar 21;18(11):1262-9. doi: 10.3748/wjg.v18.i11.1262.
To investigate the incidence and mortality of gastric cancer (GC) in Zhuanghe region, northeast China and the influencing factors for their changing trends.
All new cancer cases and deaths registered from 2005 to 2010 in Zhuanghe County were reviewed. The annual GC cases, constituent ratio, crude rates, age-standardized rates, their sex and age distribution and temporal trends were assessed. The method of annual percentage change (APC) was used to estimate the trends of GC.
Altogether 2634 new cases of GC and 1722 related deaths were registered, which accounted for 21.04% and 19.13% of all cancer-related incidence and deaths, respectively. The age-standardized incidence rate steadily decreased from 57.48 in 2005 to 44.53 in 2010 per 10(5) males, and from 18.13 to 14.70 per 10(5) females, resulting in a APC of -5.81% for males and -2.89% for females over the entire period. The magnitude of APC in GC mortality amounted to -11.09% and -15.23%, respectively, as the age-standardized mortality rate steadily decreased from 42.08 in 2005 to 23.71 in 2010 per 10(5) males, and from 23.86 to 10.78 per 10(5) females. Females had a significantly lower incidence (a male/female ratio 2.80, P < 0.001) and mortality (a male/female ratio 2.30, P < 0.001). In both genders, the peak incidence and mortality occurred in the 80-84 years age group. The age-standardized mortality/incidence ratio also decreased from the peak of 0.73 in 2005 to 0.53 in 2010 for males, and from 1.32 to 0.73 for females.
Encouraging declines of incidence and mortality of GC were observed in Zhuanghe region between 2005 and 2010, possibly due to the economic development and efficient GC control strategies.
调查中国东北庄河地区胃癌（GC）的发病率和死亡率，以及其变化趋势的影响因素。
对 2005 年至 2010 年庄河县登记的所有新癌症病例和死亡病例进行了回顾。评估了每年 GC 病例、构成比、粗率、年龄标准化率及其性别和年龄分布以及时间趋势。采用年度百分比变化（APC）的方法来估计 GC 的趋势。
共登记 2634 例新 GC 病例和 1722 例相关死亡病例，占所有癌症相关发病和死亡的 21.04%和 19.13%。年龄标准化发病率男性从 2005 年的 57.48 例/10 万持续下降至 2010 年的 44.53 例/10 万，女性从 18.13 例/10 万降至 14.70 例/10 万，整个时期男性的 APC 为-5.81%，女性为-2.89%。GC 死亡率的 APC 幅度分别为-11.09%和-15.23%，随着年龄标准化死亡率从 2005 年的 42.08 例/10 万持续下降至 2010 年的 23.71 例/10 万，男性和 23.86 例/10 万降至 10.78 例/10 万，男性和女性的 APC 分别为-11.09%和-15.23%。女性的发病率（男女比为 2.80，P < 0.001）和死亡率（男女比为 2.30，P < 0.001）均显著较低。在两性中，发病率和死亡率的峰值均出现在 80-84 岁年龄组。男性的年龄标准化死亡率/发病率比值也从 2005 年的 0.73 高峰下降至 2010 年的 0.53，女性从 1.32 下降至 0.73。
2005 年至 2010 年庄河地区 GC 的发病率和死亡率呈下降趋势，这可能归因于经济发展和有效的 GC 控制策略。
