Hobson W, Coulston F, Faiman C, Winter J S, Reyes F
J Toxicol Environ Health. 1976 Mar;1(4):657-68. doi: 10.1080/15287397609529364.
Similarities between reproductive processes in humans and chimpanzees have led to speculation that the chimpanzee might be an excellent reproductive-endocrine model of humans. Data comparing patterns and concentrations of serum gonadotropins, prolactin, and sex steroids in female humans, chimpanzees, and rhesus monkeys sustain this concept. The striking evidence that levels of estrone, estradiol, estriol, progesterone, and chorionic gonadotropin are similar during human and chimpanzee pregnancy support the contention that chimpanzees, like humans but unlike rhesus monkeys, have a definitive fetoplacental unit. Likewise, during normal menstrual cycles serum patterns of LH, FSH, progesterone, and estradiol are similar in women and chimpanzees, but differ in rhesus monkeys. Thus by using the chimpanzee it may be possible to accurately assess the safety for human use of compounds that might affect reproductive-endocrine processes without direct exposure to humans.
人类与黑猩猩生殖过程的相似性引发了一种推测，即黑猩猩可能是人类优秀的生殖内分泌模型。比较人类女性、黑猩猩和恒河猴血清促性腺激素、催乳素和性类固醇的模式及浓度的数据支持了这一概念。雌酮、雌二醇、雌三醇、孕酮和绒毛膜促性腺激素水平在人类和黑猩猩孕期相似，这一显著证据支持了这样的观点：与人类一样但与恒河猴不同，黑猩猩拥有明确的胎儿 - 胎盘单位。同样，在正常月经周期中，女性和黑猩猩的促黄体生成素（LH）、促卵泡生成素（FSH）、孕酮和雌二醇的血清模式相似，但与恒河猴不同。因此，通过使用黑猩猩，有可能在不直接接触人类的情况下准确评估可能影响生殖内分泌过程的化合物对人类使用的安全性。
