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永久性心脏起搏器系统治疗动脉性高血压:关于影响心脏与动脉系统间失调协调可能性的病例报告(作者译)

[The treatment of excessive arterial hypertension by a permanent cardiac pacemaker system: a case report concerning the possibility to influence the disturbed harmonization between the heart and the arterial system (author's transl)].

作者信息

Schaefer J, Schöttler M

出版信息

Klin Wochenschr. 1976 Mar 15;54(6):277-81. doi: 10.1007/BF01468923.

Abstract

In a 63 year old female patient with a history of longstanding arterial hypertension the implantation of a permanent cardiac pacemaker system resulted in a drastic reduction of the elevated blood pressure values, allowing to reduce the formerly necessary high dosage of antihypertensive drugs. It can be assumed that in the case presented the insertion of the permanent pacemaker leads to several hemodynamic changes: firstly, the heart rate is elevated slightly, secondly, the course of the ejection of the stroke volume is changed and consequently the contour of the pulse wave. Especially the latter factor may have an influence on various regulating mechanisms of the circulatory system and thereby on the lowering of the arterial blood pressure and the consecutive reduction of the hypertrophy of the left ventricle. Most probably the baroreceptor reflex system may be of additional great importance. In addition the "desynchronization" of the spread of excitation by the cardiac pacer might be assumed to change the action of the heart in the beginning of the ejection phase into a "softer" way of pumping. The alteration of a rather "rigid" pump (during normal excitation) into a "soft" pump (during desynchronized excitation) thus may lead to a lowering of the arterial pressure a) by decreasing the speed of ejection of the stroke volume and b) by improving the matching between the heart and the arterial "Windkessel".

摘要

在一位患有长期动脉高血压病史的63岁女性患者中,植入永久性心脏起搏器系统导致血压升高值大幅降低,从而能够减少先前所需的高剂量抗高血压药物。可以推测,在该病例中,永久性起搏器的植入导致了几种血流动力学变化:首先,心率略有升高;其次,每搏输出量的射血过程发生改变,进而脉搏波的形态也发生改变。尤其是后一个因素可能会影响循环系统的各种调节机制,从而影响动脉血压的降低以及左心室肥厚的持续减轻。最有可能的是,压力感受器反射系统可能也非常重要。此外,可以推测心脏起搏器引起的兴奋传播“不同步”可能会使射血期开始时心脏的作用转变为一种“更柔和”的泵血方式。因此,将相当“僵硬”的泵(在正常兴奋期间)转变为“柔和”的泵(在不同步兴奋期间)可能会通过以下方式导致动脉压降低:a)降低每搏输出量的射血速度;b)改善心脏与动脉“弹性贮器”之间的匹配。

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