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游离脂肪酸对心室肌电生理特性的影响。

Effects of free fatty acids on electrophysiological properties of ventricular myocardium.

作者信息

Lüderitz B, Naumann d'Alnocourt C, Steinbeck G

出版信息

Klin Wochenschr. 1976 Apr 1;54(7):309-13. doi: 10.1007/BF01471576.

DOI:10.1007/BF01471576
PMID:1263406
Abstract

Several metabolic factors have been regarded as a cause of ventricular tachyarrhythmias in cardiac ischemia, i.e. hypoxia, acidosis, intracellular potassium loss, local catecholamine release as well as an increased catecholamine concentration and an evaluation of serum free fatty acids. The arrhythmogenic properties of anoxia and hypoxic acidosis, catecholamines as well as potassium depletion are well known. However, the relationship between elevated free fatty acids concentration and the occurrence of ventricular arrhythmias remain obscure. The micro-electrode technique was applied to examine the electrophysiological effects of free fatty acids in papillary heart muscle fibres. Both linoleate and palmitate cause a concentration-dependent decrease of action potential duration and a corresponding shortening of the functional refractory period in the presence of sufficient oxygen supply. The results suggest that a high concentration of free fatty acids may play an additional role in the genesis of ventricular tachyarrhythmias in cardiac ischemia.

摘要

几种代谢因素被认为是心脏缺血时室性快速性心律失常的原因,即缺氧、酸中毒、细胞内钾丢失、局部儿茶酚胺释放以及儿茶酚胺浓度升高和血清游离脂肪酸的评估。缺氧和低氧酸中毒、儿茶酚胺以及钾缺乏的致心律失常特性是众所周知的。然而,游离脂肪酸浓度升高与室性心律失常发生之间的关系仍不清楚。应用微电极技术研究游离脂肪酸对乳头肌纤维的电生理效应。在有充足氧气供应的情况下,亚油酸和棕榈酸均会导致动作电位时程呈浓度依赖性缩短以及功能不应期相应缩短。结果表明,高浓度游离脂肪酸可能在心脏缺血时室性快速性心律失常的发生中起额外作用。

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1
Effects of free fatty acids on electrophysiological properties of ventricular myocardium.游离脂肪酸对心室肌电生理特性的影响。
Klin Wochenschr. 1976 Apr 1;54(7):309-13. doi: 10.1007/BF01471576.
2
[Influence of free fatty acids on electrophysiological data of ventricular myocardium].[游离脂肪酸对心室心肌电生理数据的影响]
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引用本文的文献

1
Palmitate attenuates myocardial contractility through augmentation of repolarizing Kv currents.软脂酸通过增强复极化 Kv 电流来减弱心肌收缩力。
J Mol Cell Cardiol. 2010 Feb;48(2):395-405. doi: 10.1016/j.yjmcc.2009.10.004. Epub 2009 Oct 24.

本文引用的文献

1
Acid-base studies in experimental circulatory arrest.
Lancet. 1962 Nov 10;2(7263):967-9. doi: 10.1016/s0140-6736(62)90730-4.
2
Microdetermination of long-chain fatty acids in plasma and tissues.血浆和组织中长链脂肪酸的微量测定
J Biol Chem. 1960 Sep;235:2595-9.
3
[The action current of the myocardial fibers in oxygen deficiency].[缺氧状态下心肌纤维的动作电流]
Pflugers Arch Gesamte Physiol Menschen Tiere. 1954;260(1):40-60. doi: 10.1007/BF00363778.
4
Toxic effects of glucagon-induced acute lipid mobilization in geese.胰高血糖素诱导的鹅急性脂质动员的毒性作用。
J Clin Invest. 1968 Dec;47(12):2701-10. doi: 10.1172/JCI105953.
5
Free fatty acids and myocardial function in perfused rat hearts.
Cardiovasc Res. 1970 Oct;4(4):466-72. doi: 10.1093/cvr/4.4.466.
6
Plasma free fatty acid and catecholamine levels in patients with acute myocardial infarction.急性心肌梗死患者的血浆游离脂肪酸和儿茶酚胺水平
Br Heart J. 1971 Sep;33(5):716-8. doi: 10.1136/hrt.33.5.716.
7
Effect of free fatty acids on myocardial function and oxygen consumption in intact dogs.游离脂肪酸对完整犬心肌功能和氧消耗的影响。
J Clin Invest. 1971 Jul;50(7):1386-9. doi: 10.1172/JCI106621.
8
Effect of free fatty acids on myocardial function and metabolism in the ischemic dog heart.游离脂肪酸对缺血犬心脏心肌功能和代谢的影响。
J Clin Invest. 1972 Jul;51(7):1767-76. doi: 10.1172/JCI106978.
9
Serum cortisol, plasma free fatty acids, and urinary cathecholamines as indicators of complications in acute myocardial infarction.血清皮质醇、血浆游离脂肪酸和尿儿茶酚胺作为急性心肌梗死并发症的指标。
Circulation. 1972 Apr;45(4):736-45. doi: 10.1161/01.cir.45.4.736.
10
Metabolic response during impending myocardial infarction. I. Relevance of studies of glucose and fatty acid metabolism in animals.心肌梗死即将发生时的代谢反应。I. 动物体内葡萄糖和脂肪酸代谢研究的相关性。
Circulation. 1972 Feb;45(2):483-90. doi: 10.1161/01.cir.45.2.483.