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病毒诱导发热致畸作用的实验研究(作者译)

[Experimental studies to the teratogen effects of virus-induced fever (author's transl)].

作者信息

Hellmann W, Grote W

出版信息

Klin Wochenschr. 1976 Apr 1;54(7):333-4. doi: 10.1007/BF01471579.

Abstract

Fever was induced in pregnant rabbits at the 9th day of gestation by injection of a heat inactivated virus which had not lost its pyrogenic activity. The mother rabbits were killed on the 29th day of pregnancy, the fetuses taken out and the uteri examined for resorptions. The fetuses were inspected for organ malformations macroscopically and for skeleten malformations microscopically. The results were compared with those of control animals. The rise of temperature up to a maximum 2,1 degrees C above normal temperature resulted in no higher resorption and malformation rate.

摘要

在妊娠第9天,通过注射热灭活但仍具有致热活性的病毒使怀孕兔子发热。在怀孕第29天处死母兔,取出胎儿并检查子宫是否有吸收情况。对胎儿进行肉眼检查器官畸形情况,并进行显微镜检查骨骼畸形情况。将结果与对照动物的结果进行比较。体温升高至比正常体温最高高2.1摄氏度,并未导致更高的吸收和畸形率。

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