Choi Yoon-Ho, Kim Ji-Hae, Kim Doh Kwan, Kim Jong-Won, Kim Duk-Kyung, Lee Mee Sook, Kim Cheol Ho, Park Sang Chul
Department of Internal Medicine, Sungkyunkwan University School of Medicine, Seoul, Korea.
J Gerontol A Biol Sci Med Sci. 2003 Mar;58(3):227-31. doi: 10.1093/gerona/58.3.m227.
Genetic polymorphisms of angiotensin-converting enzyme (ACE) and apolipoprotein E (APOE) have been reported to be associated with human longevity and dementia in the elderly. However, whether such putative longevity genes exert the same effects on different ethnic groups living in different environments is not well known.
We investigated the distributions of the ACE and APOE genotypes and their relations with dementia status in Korean centenarians by cross-sectional study. A total of 103 centenarians (13 men and 90 women, mean age 102.4 +/- 2.6 years) were included in this study. The allele frequencies of the genes were compared with those of two control groups: 7232 apparently healthy adults (4100 men and 3132 women) of mean age 48.5 +/- 9.6 years for the ACE genotyping, and 6435 adults (5008 men and 1427 women) of mean age 50.7 +/- 7.9 years for the APOE genotyping. The dementia status of the centenarians was assessed by clinical psychologist using the Clinical Dementia Rating (CDR) score.
The frequencies of genotypes and alleles of the ACE and APOE genes of the centenarians were not significantly different from those of the control groups. There was a lack of association between presence of the D allele on the ACE gene and dementia status. However, the frequency of the epsilon4 allele of the APOE gene was significantly higher in centenarians with dementia than in centenarians without definitive dementia (9.1% versus 1.5%, p <.05).
These results suggest that neither the ACE nor the APOE gene is significantly associated with longevity in the Korean population, but that the APOE epsilon4 allele is still related with dementia even at age 100 and older.
据报道，血管紧张素转换酶（ACE）和载脂蛋白E（APOE）的基因多态性与老年人的人类长寿和痴呆症有关。然而，这些假定的长寿基因对生活在不同环境中的不同种族群体是否具有相同的影响尚不清楚。
我们通过横断面研究调查了韩国百岁老人中ACE和APOE基因型的分布及其与痴呆症状态的关系。本研究共纳入103名百岁老人（13名男性和90名女性，平均年龄102.4±2.6岁）。将这些基因的等位基因频率与两个对照组进行比较：7232名平均年龄48.5±9.6岁的明显健康成年人（4100名男性和3132名女性）用于ACE基因分型，6435名平均年龄50.7±7.9岁的成年人（5008名男性和1427名女性）用于APOE基因分型。临床心理学家使用临床痴呆评定量表（CDR）评分评估百岁老人的痴呆症状态。
百岁老人的ACE和APOE基因的基因型和等位基因频率与对照组无显著差异。ACE基因上D等位基因的存在与痴呆症状态之间缺乏关联。然而，患有痴呆症的百岁老人中APOE基因的ε4等位基因频率显著高于没有明确痴呆症的百岁老人（9.1%对1.5%，p<.05）。
这些结果表明，ACE基因和APOE基因均与韩国人群的长寿无显著关联，但APOEε4等位基因即使在100岁及以上的年龄仍与痴呆症有关。
