丙型肝炎病毒（HCV）复制子细胞培养系统中HCV RNA合成的细胞骨架要求
Cytoskeletal requirements for hepatitis C virus (HCV) RNA synthesis in the HCV replicon cell culture system.
作者信息
Bost Anne G, Venable Daryl, Liu Lifei, Heinz Beverly A
机构信息
Infectious Diseases Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285-0438, USA.
出版信息
J Virol. 2003 Apr;77(7):4401-8. doi: 10.1128/jvi.77.7.4401-4408.2003.
Abstract
Hepatitis C virus (HCV) induces microtubule aggregates in infected hepatocytes. To determine if cytoskeletal elements are important for HCV RNA synthesis, we examined the effect of cytoskeleton inhibitors on HCV replicon transcription in Huh7 cells. The data demonstrate that HCV replication complex-mediated RNA synthesis requires microtubule and actin polymerization.
摘要
丙型肝炎病毒（HCV）在受感染的肝细胞中诱导微管聚集。为了确定细胞骨架成分对HCV RNA合成是否重要，我们检测了细胞骨架抑制剂对Huh7细胞中HCV复制子转录的影响。数据表明，HCV复制复合体介导的RNA合成需要微管和肌动蛋白聚合。
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