Exton Michael S, Artz Mike, Siffert Winfried, Schedlowski Manfred
Deparment of Medical Psychology, University Clinic of Essen, Germany.
Neuroreport. 2003 Mar 3;14(3):531-3. doi: 10.1097/00001756-200303030-00047.
This study investigated the relationship between the G protein beta3 subunit 825T allele and depression in young, healthy subjects. 825T and 825C allele carriers were characterized among 190 healthy medical students. State depression was assessed by the Becks Depression Inventory, supplemented by subscales of the Freiburg Personality Inventory, and Questionnaire for Measuring Factors of Aggression which assess trait depression. Depression of homo- and heterozygous 825T allele carriers was compared to 825C allele carriers via multi-level statistical analysis. 825T allele carriers displayed higher levels of depression, as measured by each questionnaire. Regression analysis demonstrated that allele type was the single predictor of depression. The predictive capacity of the 825T allele in depression was further supported by odds-ratio analysis. We conclude that the G protein beta3 subunit 825T allele is predictive of depressive mood in a young, healthy population.
本研究调查了年轻健康受试者中G蛋白β3亚基825T等位基因与抑郁症之间的关系。在190名健康医学生中对825T和825C等位基因携带者进行了特征分析。通过贝克抑郁量表评估状态抑郁，并辅以弗莱堡人格量表的分量表以及评估特质抑郁的攻击因子测量问卷。通过多水平统计分析，将纯合和杂合825T等位基因携带者的抑郁情况与825C等位基因携带者进行比较。根据每份问卷测量，825T等位基因携带者表现出更高水平的抑郁。回归分析表明等位基因类型是抑郁的唯一预测因子。优势比分析进一步支持了825T等位基因在抑郁症中的预测能力。我们得出结论，G蛋白β3亚基825T等位基因可预测年轻健康人群的抑郁情绪。
