Lindemann M, Virchow S, Ramann F, Barsegian V, Kreuzfelder E, Siffert W, Müller N, Grosse-Wilde H
Institut für Immunologie, Universitätsklinikum, 45122 Essen, Germany.
FEBS Lett. 2001 Apr 20;495(1-2):82-6. doi: 10.1016/s0014-5793(01)02339-0.
The G protein beta3 subunit (GNB3) 825T allele is predictive of enhanced Gi protein activation. Studying the influence of C825T allele status on cellular in vitro immune responses towards recall antigens and interleukin-2 stimulation we observed a 2-4-fold, significantly increased proliferation in homozygous 825T (TT) vs. C825 allele (CC) carriers. Furthermore, lymphocyte chemotaxis and CD4(+) T cell counts of individuals with TT+TC genotypes were significantly enhanced compared to the CC genotype. In summary, it appears that C825T allele status is highly predictive of immunocompetence and could be a candidate gene in disorders associated with inadequate immune response.
G蛋白β3亚基（GNB3）825T等位基因可预测Gi蛋白激活增强。在研究C825T等位基因状态对细胞体外针对回忆抗原和白细胞介素-2刺激的免疫反应的影响时，我们观察到，与C825等位基因（CC）携带者相比，纯合825T（TT）携带者的增殖显著增加了2至4倍。此外，与CC基因型相比，TT + TC基因型个体的淋巴细胞趋化性和CD4(+) T细胞计数显著增强。总之，C825T等位基因状态似乎高度可预测免疫能力，并且可能是与免疫反应不足相关疾病的候选基因。
