Moritz N, Jokinen M, Peltola T, Areva S, Yli-Urpo A
Institute of Dentistry & Biomaterials Research, University of Turku, Turku, Finland.
J Biomed Mater Res A. 2003 Apr 1;65(1):9-16. doi: 10.1002/jbm.a.10434.
Sol-gel-derived TiO(2) coatings are known to promote bonelike hydroxyapatite formation on their surfaces in vitro and in vivo. Hydroxyapatite integrates into bone tissue. In some clinical applications, the surface of an implant is simultaneously interfaced with soft and hard tissues, so it should match the properties of both. A new method is introduced for treating the coatings locally in a controlled manner. The local densification of sol-gel-derived titania coatings on titanium substrates with a CO(2) laser was studied in terms of the in vitro calcium phosphate-inducting properties. CO(2)-laser-treated multilayer coatings were compared with furnace-fired coatings prepared with the same recipe and previously shown to be bioactive. Additionally, local areas of furnace-fired multilayer coatings (previously shown to be bioactive in vitro) were further laser-treated to achieve various properties in the same implant. Topological surface properties were examined with atomic force microscopy. The formation of hydroxyapatite was studied with Fourier transform infrared and scanning electron microscopy energy-dispersive X-ray analysis. The results show that calcium phosphate formation can be adjusted locally by laser treatment. Calcium phosphate is a bonelike hydroxyapatite. The local treatment of sol-gel-derived coatings with a CO(2) laser is a promising technique for creating implants with various properties to interface different tissues and a possible way of coating implants that do not tolerate furnace firing.
溶胶 - 凝胶法制备的TiO₂涂层在体外和体内均能促进其表面形成类骨羟基磷灰石。羟基磷灰石可整合到骨组织中。在一些临床应用中，植入物表面会同时与软组织和硬组织接触，因此其表面性质应与两者都相匹配。本文介绍了一种以可控方式对涂层进行局部处理的新方法。研究了用CO₂激光对钛基底上溶胶 - 凝胶法制备的二氧化钛涂层进行局部致密化处理后的体外诱导磷酸钙的性能。将CO₂激光处理的多层涂层与采用相同配方制备且先前已证明具有生物活性的炉烧涂层进行了比较。此外，对炉烧多层涂层（先前已证明在体外具有生物活性）的局部区域进一步进行激光处理，以在同一植入物上实现各种性能。用原子力显微镜检查拓扑表面性质。用傅里叶变换红外光谱和扫描电子显微镜 - 能量色散X射线分析研究羟基磷灰石的形成。结果表明，通过激光处理可以局部调节磷酸钙的形成。所形成的磷酸钙为类骨羟基磷灰石。用CO₂激光对溶胶 - 凝胶法制备的涂层进行局部处理是一种很有前景的技术，可用于制造具有各种性能以与不同组织结合的植入物，也是一种对不耐受炉烧的植入物进行涂层处理的可行方法。
