与HLA - B51相关的赖特综合征：一例报告

Reiter's syndrome associated with HLA-B51: a case report.

作者信息

Taniguchi Y, Yorioka N, Kyuden Y, Asakimori Y

机构信息

Division of Blood Purification, Hiroshima University Hospital, Hiroshima, Japan.

出版信息

J Int Med Res. 2003 Jan-Feb;31(1):55-7. doi: 10.1177/147323000303100109.

DOI:10.1177/147323000303100109

PMID:12635535

Abstract

A 32-year-old Japanese man developed polyarthritis with mild fever and conjunctivitis. Clinical assessment indicated non-specific arthritis, aseptic pyuria induced by infection with Chlamydia, and conjunctivitis. He was diagnosed with reactive arthritis (Reiter's syndrome). Serotyping of human leucocyte antigen (HLA) class I and II revealed positivity for B51(5), A2, A33(19), B44(12), Cw1, DR4 and DR6, but B27 was negative. He was treated with a combination of doxycycline, oral prednisolone, diclofenac sodium and salazosulphapyridine. Fever and arthralgia improved and he became negative for anti-Chlamydia immunoglobulin (Ig) A and IgG antibodies. HLA-B51 may be involved in the pathogenesis of Reiter's syndrome in this Japanese patient.

摘要

一名32岁的日本男性出现了多关节炎，并伴有低热和结膜炎。临床评估显示为非特异性关节炎、衣原体感染引起的无菌性脓尿症以及结膜炎。他被诊断为反应性关节炎（赖特综合征）。人类白细胞抗原（HLA）I类和II类的血清分型显示B51(5)、A2、A33(19)、B44(12)、Cw1、DR4和DR6呈阳性，但B27为阴性。他接受了强力霉素、口服泼尼松龙、双氯芬酸钠和柳氮磺胺吡啶的联合治疗。发热和关节痛有所改善，抗衣原体免疫球蛋白（Ig）A和IgG抗体检测转为阴性。HLA - B51可能参与了这名日本患者赖特综合征的发病机制。