Müller N, Lange C E
Fortschr Med. 1977 Jun 16;95(23):1509-12.
The prevalence of 23 HLA antigens were examined in 21 patients with a typical Reiter's disease, 21 patients with incomplete Reiter's syndrome as well as 16 patients with non-gonococcal urethritis. HLA-B 27 antigen was found in 85,7% of patients with typical Reiter's disease as compared to 7,4% of 413 healthy controls. HLA-B 27 was also detectable in 57,1% of patients with clinical suspicion of Reiter's disease. No significant difference from the control frequencies of HLA specifities was found in patients with non-gonococcal urethritis. The association between HLA-B 27 and Reiter's syndrome is so marked that tissue typing is a valuable adjunct in the diagnosis of Reiter's syndrome.
对21例典型赖特综合征患者、21例不完全性赖特综合征患者以及16例非淋菌性尿道炎患者检测了23种HLA抗原的流行情况。典型赖特综合征患者中85.7%发现有HLA - B27抗原，而413名健康对照者中该抗原阳性率为7.4%。临床怀疑为赖特综合征的患者中57.1%也可检测到HLA - B27。非淋菌性尿道炎患者的HLA特异性对照频率无显著差异。HLA - B27与赖特综合征之间的关联非常明显，以至于组织分型在赖特综合征的诊断中是一项有价值的辅助手段。
