Sohn Myung Hyun, Kim Cheol Hong, Kim Woo Kyung, Jang Gwang Cheon, Kim Kyu-Earn
Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea.
Allergy Asthma Proc. 2003 Jan-Feb;24(1):67-71.
Exotoxins secreted by Staphylococcus aureus have been identified as a possible trigger factor in atopic dermatitis (AD). We investigated the production and role of circulating antibodies, with specificity to staphylococcal enterotoxin B (SEB), in children with AD compared with those of healthy controls. The children with AD had significantly higher levels of serum SEB-specific immunoglobulin G (IgG; p = 0.0193), IgM (p = 0.011), and IgE (p = 0.0001) than the nonatopic children. The proportions of IgG, IgM, and IgE seropositivity in children with AD were 52.5% (21/40), 62.5% (25/40), and 67.5% (27/40), respectively. The levels of SEB-specific IgE and the severity of AD (p = 0.0004) were compared, but no correlation was seen for IgG or IgM. SEB may be involved in exacerbation of AD. SEB-specific IgE may be an important index of the clinical severity of AD. The SEB-specific IgG or IgM was produced during the exposure to the SEB antigen but may not be protective against SEB in AD.
金黄色葡萄球菌分泌的外毒素已被确定为特应性皮炎（AD）的一个可能触发因素。我们调查了与健康对照相比，AD患儿中对葡萄球菌肠毒素B（SEB）具有特异性的循环抗体的产生情况及作用。AD患儿的血清SEB特异性免疫球蛋白G（IgG；p = 0.0193）、IgM（p = 0.011）和IgE（p = 0.0001）水平显著高于非特应性儿童。AD患儿中IgG、IgM和IgE血清阳性比例分别为52.5%（21/40）、62.5%（25/40）和67.5%（27/40）。比较了SEB特异性IgE水平与AD严重程度（p = 0.0004），但未发现IgG或IgM存在相关性。SEB可能参与AD的病情加重。SEB特异性IgE可能是AD临床严重程度的一个重要指标。SEB特异性IgG或IgM是在接触SEB抗原期间产生的，但在AD中可能对SEB没有保护作用。
