Division of Dermatology and Venereology, Department of Clinical Sciences, Lund University, Skåne University Hospital, Lund, Sweden.
Section of Rheumatology, Department of Clinical Sciences Lund, Lund University, Skåne University Hospital, Lund, Sweden.
Acta Derm Venereol. 2023 Mar 30;103:adv2405. doi: 10.2340/actadv.v103.2405.
Atopic dermatitis is a relapsing inflammatory skin condition, in which bacteria, fungi and viruses may colonize the skin and aggravate the condition. Mannose-binding lectin is part of the innate immune system. Polymorphism in the mannose-binding lectin gene can result in deficiency of mannose-binding lectin, which may affect defence against microbes. The aim of this study was to investigate whether polymorphisms in the mannose-binding lectin gene affect the extent of sensitization to common skin microbes, the skin barrier function, or the severity of the disease in a cohort of patients with atopic dermatitis. Genetic testing of mannose-binding lectin polymorphism was performed in 60 patients with atopic dermatitis. The disease severity, skin barrier function, and serum levels of specific immunoglobulin E against skin microbes were measured. In patients with low mannose-binding lectin genotype (group 1) 6 of 8 (75%) were sensitized to Candida albicans, compared to 14 of 22 (63.6%) patients with intermediate mannose-binding genotype (group 2) and 10 of 30 (33.3%) patients with high mannose-binding genotype (group 3). Group 1 (low mannose-binding lectin) was more likely to be sensitized to Candida albicans compared with group 3 (high mannose-binding lectin) (odds ratio 6.34, p-value 0.045). In this cohort of patients with atopic dermatitis, mannose-binding lectin deficiency was associated with increased sensitization to Candida albicans.
特应性皮炎是一种反复发作的炎症性皮肤病，其中细菌、真菌和病毒可能定植于皮肤并加重病情。甘露糖结合凝集素是固有免疫系统的一部分。甘露糖结合凝集素基因的多态性可导致甘露糖结合凝集素缺乏，这可能会影响对微生物的防御。本研究旨在调查特应性皮炎患者队列中甘露糖结合凝集素基因多态性是否影响对常见皮肤微生物的致敏程度、皮肤屏障功能或疾病严重程度。对 60 例特应性皮炎患者进行了甘露糖结合凝集素多态性的基因检测。测量了疾病严重程度、皮肤屏障功能和针对皮肤微生物的特异性免疫球蛋白 E 的血清水平。低甘露糖结合凝集素基因型（组 1）的 8 例患者中有 6 例（75%）对白色念珠菌过敏，而中间甘露糖结合基因型（组 2）的 22 例患者中有 14 例（63.6%）和高甘露糖结合基因型（组 3）的 30 例患者中有 10 例（33.3%）。与组 3（高甘露糖结合）相比，组 1（低甘露糖结合）更有可能对白色念珠菌过敏（比值比 6.34，p 值为 0.045）。在本队列的特应性皮炎患者中，甘露糖结合凝集素缺乏与对白色念珠菌的致敏增加相关。
