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丙硫氧嘧啶治疗后出现肝功能损害的甲亢合并妊娠患者使用卡比马唑成功治疗:一例病例报告

Successful treatment with carbimazole of a hyperthyroid pregnancy with hepatic impairment after propylthiouracil administration: a case report.

作者信息

Kontoleon P, Ilias I, Koutras D A, Kontogiannis D, Papapetrou P D

机构信息

Second Endocrine Department, Alexandra General Hospital, Athens, Greece.

出版信息

Clin Exp Obstet Gynecol. 2002;29(4):304-5.

PMID:12635752
Abstract

We report the case of a 27-year-old woman with hyperthyroidism during pregnancy. Antithyroid treatment with propylthiouracil (PTU) resulted in elevated hepatic enzymes and after the 12th week of pregnancy treatment was changed to carbimazole (CBZ). The remaining pregnancy, delivery and follow-up period were uneventful for the mother and her offspring. Antithyroid treatment during pregnancy should allow the use not only of PTU but also of CBZ and methimazole.

摘要

我们报告了一例27岁妊娠期甲状腺功能亢进症女性患者的病例。使用丙硫氧嘧啶(PTU)进行抗甲状腺治疗导致肝酶升高,妊娠12周后治疗改为卡比马唑(CBZ)。母亲及其后代在剩余的孕期、分娩期及随访期均平安无事。妊娠期抗甲状腺治疗不仅应允许使用PTU,还应允许使用CBZ和甲巯咪唑。

相似文献

1
Successful treatment with carbimazole of a hyperthyroid pregnancy with hepatic impairment after propylthiouracil administration: a case report.丙硫氧嘧啶治疗后出现肝功能损害的甲亢合并妊娠患者使用卡比马唑成功治疗:一例病例报告
Clin Exp Obstet Gynecol. 2002;29(4):304-5.
2
Propylthiouracil, and methimazole, and carbimazole-related hepatotoxicity.丙硫氧嘧啶、甲巯咪唑及卡比马唑相关的肝毒性。
Expert Opin Drug Saf. 2014 Oct;13(10):1397-406. doi: 10.1517/14740338.2014.953796. Epub 2014 Aug 26.
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Safety of antithyroid drugs in pregnancy: update and therapy implications.抗甲状腺药物在孕期的安全性:最新进展及治疗意义
Expert Opin Drug Saf. 2020 May;19(5):565-576. doi: 10.1080/14740338.2020.1748007. Epub 2020 Apr 1.
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Antithyroid drug-related hepatotoxicity in hyperthyroidism patients: a population-based cohort study.甲亢患者抗甲状腺药物相关肝毒性:一项基于人群的队列研究。
Br J Clin Pharmacol. 2014 Sep;78(3):619-29. doi: 10.1111/bcp.12336.
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Treatment of hyperthyroidism in pregnancy and birth defects.妊娠期甲状腺功能亢进症的治疗与出生缺陷。
J Clin Endocrinol Metab. 2010 Nov;95(11):E337-41. doi: 10.1210/jc.2010-0652. Epub 2010 Jul 28.
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Birth defects after early pregnancy use of antithyroid drugs: a Danish nationwide study.早孕使用抗甲状腺药物后的出生缺陷:一项丹麦全国性研究。
J Clin Endocrinol Metab. 2013 Nov;98(11):4373-81. doi: 10.1210/jc.2013-2831. Epub 2013 Oct 22.
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Pharmacologic treatment of hyperthyroidism during pregnancy.妊娠期甲状腺功能亢进症的药物治疗。
Birth Defects Res A Clin Mol Teratol. 2012 Aug;94(8):612-9. doi: 10.1002/bdra.23012. Epub 2012 Apr 18.
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Risk of adverse perinatal outcomes with antithyroid treatment during pregnancy: a nationwide population-based study.妊娠期抗甲状腺药物治疗的不良围生期结局风险:一项全国范围内基于人群的研究。
BJOG. 2011 Oct;118(11):1365-73. doi: 10.1111/j.1471-0528.2011.03019.x. Epub 2011 May 31.
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The safety of methimazole and propylthiouracil in pregnancy: a systematic review.甲巯咪唑和丙硫氧嘧啶在孕期的安全性:一项系统评价。
J Obstet Gynaecol Can. 2012 Nov;34(11):1077-1086. doi: 10.1016/S1701-2163(16)35438-X.
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[The use of antithyroid drugs should be reduced as much as possible in the first trimester].在孕早期应尽可能减少抗甲状腺药物的使用。
Ugeskr Laeger. 2014 Sep 22;176(39).

引用本文的文献

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Liver injury associated with drug intake during pregnancy.孕期药物摄入相关的肝损伤。
World J Hepatol. 2021 Jul 27;13(7):747-762. doi: 10.4254/wjh.v13.i7.747.
2
Side effects of anti-thyroid drugs and their impact on the choice of treatment for thyrotoxicosis in pregnancy.抗甲状腺药物的副作用及其对妊娠期甲状腺毒症治疗选择的影响。
Eur Thyroid J. 2012 Oct;1(3):176-85. doi: 10.1159/000342920. Epub 2012 Sep 24.
3
Frequency of Adverse Events of Antithyroid Drugs Administered during Pregnancy.孕期使用抗甲状腺药物的不良事件发生率。
J Thyroid Res. 2014;2014:952352. doi: 10.1155/2014/952352. Epub 2014 Jan 9.
4
Propylthiouracyl-induced severe liver toxicity: an indication for alanine aminotransferase monitoring?丙硫氧嘧啶引起的严重肝毒性:是否需要监测丙氨酸氨基转移酶?
World J Gastroenterol. 2006 Oct 14;12(38):6232-4. doi: 10.3748/wjg.v12.i38.6232.